Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats

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dc.citation.issue21
dc.citation.volume594
dc.contributor.authorPijacka, Wioletta
dc.contributor.authorMcBryde, Fiona D.
dc.contributor.authorMarvar, Paul J.
dc.contributor.authorLincevicius, Gisele S. [UNIFESP]
dc.contributor.authorAbdala, Ana Paula Lima [UNIFESP]
dc.contributor.authorWoodward, Lavinia
dc.contributor.authorLi, Dan
dc.contributor.authorPaterson, David J.
dc.contributor.authorPaton, Julian F. R.
dc.coverageHoboken
dc.date.accessioned2020-07-31T12:47:29Z
dc.date.available2020-07-31T12:47:29Z
dc.date.issued2016
dc.description.abstractThe peripheral chemoreflex is known to be hyper-responsive in both spontaneously hypertensive (SHR) and Goldblatt hypertensive (two kidney one clipen
dc.description.abstract2K1C) rats. We have previously shown that carotid sinus nerve denervation (CSD) reduces arterial blood pressure (ABP) in SHR. In the present study, we show that CSD ameliorates 2K1C hypertension and reveal the potential underlying mechanisms. Adult Wistar rats were instrumented to record ABP via telemetry, and then underwent CSD (n=9) or sham CSD (n=9) 5weeks after renal artery clipping, in comparison with normal Wistar rats (n=5). After 21days, renal function was assessed, and tissue was collected to assess sympathetic postganglionic intracellular calcium transients ([Ca2+](i)) and immune cell infiltrates. Hypertensive 2K1C rats showed a profound elevation in ABP (Wistar: 984mmHg vs. 2K1C: 1478mmHgen
dc.description.abstractP<0.001), coupled with impairments in renal function and baroreflex sensitivity, increased neuroinflammatory markers and enhanced [Ca2+](I) in stellate neurons (P<0.05). CSD reduced ABP in 2K1C+CSD rats and prevented the further progressive increase in ABP seen in 2K1C+sham CSD rats, with a between-group difference of 142mmHg by week 3 (P<0.01), which was accompanied by improvements in both baroreflex control and spectral indicators of cardiac sympatho-vagal balance. Furthermore, CSD improved protein and albuminuria, decreased [Ca2+](i) evoked responses from stellate neurons, and also reduced indicators of brainstem inflammation. In summary, CSD in 2K1C rats reduces the hypertensive burden and improves renal function. This may be mediated by improvements in autonomic balance, functional remodelling of post-ganglionic neurons and reduced inflammation. Our results suggest that the peripheral chemoreflex may be considered as a potential therapeutic target for controlling renovascular hypertension.en
dc.description.affiliationUniv Bristol, Sch Physiol Pharmacol & Neurosci, Biomed Sci, Bristol, Avon, England
dc.description.affiliationUniv Auckland, Dept Physiol, Fac Med & Hlth Sci, Auckland, New Zealand
dc.description.affiliationGeorge Washington Univ, Sch Med & Hlth Sci, Dept Pharmacol & Physiol, Washington, DC 20052 USA
dc.description.affiliationUniv Fed Sao Paulo, Cardiovasc Div, Escola Paulista Med, Dept Physiol, Sao Paulo, Brazil
dc.description.affiliationUniv Oxford, Burdon Sanderson Cardiac Sci Ctr, Dept Physiol Anat & Genet, Oxford OX1 2JD, England
dc.description.affiliationUnifespCardiovascular Division ‐ Department of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipBritish Heart Foundation
dc.description.sponsorshipRoyal Society
dc.description.sponsorshipNational Institutes of Health (NIH)
dc.description.sponsorshipEuropean Commission Research Executive Agency Marie Curie International Incoming Fellowship
dc.description.sponsorshipAmerican Heart Association
dc.description.sponsorshipIDBritish Heart Foundation: RG/12/6/29670
dc.description.sponsorshipIDNIH: 1R01AT008632-01
dc.description.sponsorshipIDNIH: R00 HL107675-03
dc.description.sponsorshipIDEuropean Commission Research Executive Agency Marie Curie International Incoming Fellowship: MC-IIF - 276147
dc.description.sponsorshipIDAmerican Heart Association: 15CSA24340001
dc.format.extent6255-6266
dc.identifierhttp://dx.doi.org/10.1113/JP272708
dc.identifier.citationJournal Of Physiology-London. Hoboken, v. 594, n. 21, p. 6255-6266, 2016.
dc.identifier.doi10.1113/JP272708
dc.identifier.issn0022-3751
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56846
dc.identifier.wosWOS:000387084200016
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofJournal Of Physiology-London
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcarotid sinus denervationen
dc.subjectchemoreceptor reflexen
dc.subjectrenovascular hypertensionen
dc.titleCarotid sinus denervation ameliorates renovascular hypertension in adult Wistar ratsen
dc.typeinfo:eu-repo/semantics/article
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