The influence of nutritional status and disease on adiponectin and TNF-alpha levels in colorectal cancer patients

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dc.contributor.authorVicente, Mariana Abe [UNIFESP]
dc.contributor.authorSilva, Tiago Donizetti [UNIFESP]
dc.contributor.authorBarao, Katia [UNIFESP]
dc.contributor.authorFelipe, Aledson Vitor [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorForones, Nora Manoukian [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionDept Physiol
dc.date.accessioned2016-01-24T14:37:30Z
dc.date.available2016-01-24T14:37:30Z
dc.date.issued2014-07-01
dc.description.abstractBackground: the aim of this study was to evaluate the association between adiponectin and tumor necrosis factor-a (TNF-alpha) serum levels in colorectal cancer (CRC) patients and compare these levels to clinical stage and nutritional status.Methods: A total of 79 patients were enrolled in the study (39 with CRC and 40 in the control). Nutritional status was assessed by Patient-Generated Subjective Global Assessment (PG-SGA), body mass index (BMI), and phase angle (PhA). Adiponectin and TNF-alpha serum concentrations were determined using an enzyme-linked immunosorbent assay.Results: Serum adiponectin levels were higher among CRC patients (p = 0.001). TNF-alpha serum levels were not significantly different between the groups, but patients with stage III or IV CRC had higher levels of TNF-alpha than those with lower stage disease (p = 0.037). the three tools used for the assessment of nutritional status (BMI, PhA, and PG-SGA) demonstrated that patients with a more severe nutritional deficit had higher adipocytokine levels, although these differences were significant only to TNF-alpha, when distributed PhA in tertiles.Conclusions: Adiponectin levels were higher among CRC patients. Although TNF-alpha serum levels from CRC patients did not differ significantly to the control group, CRC patients with stage III or IV had higher levels compared to those with stage I and II tumors. Nutritional status, as determined by BMI, PhA, and PG-SGA, demonstrated that patients with a greatest nutritional deficit, had higher levels of adipocytokines; however, these differences were significant only for TNF-alpha, when distributed PhA in tertiles.en
dc.description.affiliationEscola Paulista Med, Dept Med, Div Gastroenterol, Oncol Grp, BR-04023 São Paulo, Brazil
dc.description.affiliationDept Physiol, São Paulo, Brazil
dc.description.affiliationUnifespEscola Paulista Med, Dept Med, Div Gastroenterol, Oncol Grp, BR-04023 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 10/19191-2
dc.format.extent140-146
dc.identifierhttps://dx.doi.org/10.3305/nh.2014.30.1.7132
dc.identifier.citationNutricion Hospitalaria. Madrid: Aula Medica Ediciones, v. 30, n. 1, p. 140-146, 2014.
dc.identifier.doi10.3305/nh.2014.30.1.7132
dc.identifier.fileWOS000340864700018.pdf
dc.identifier.issn0212-1611
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/37908
dc.identifier.wosWOS:000340864700018
dc.language.isoeng
dc.publisherAula Medica Ediciones
dc.relation.ispartofNutricion Hospitalaria
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdipocytokinesen
dc.subjectColorectal Canceren
dc.subjectNutrition Assessmenten
dc.titleThe influence of nutritional status and disease on adiponectin and TNF-alpha levels in colorectal cancer patientsen
dc.title.alternativeInfluencia del estado nutritivo y la enfermedad sobre las concentraciones de adiponectina y TNF-α en pacientes con cáncer colorrectales
dc.typeinfo:eu-repo/semantics/article
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