Impact of machine perfusion after long static cold storage on delayed graft function incidence and duration and time to hospital discharge

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dc.citation.issue1
dc.citation.volume32
dc.contributor.authorMatos, Ana Cristina C.
dc.contributor.authorRequiao Moura, Lucio Roberto
dc.contributor.authorBorrelli, Milton
dc.contributor.authorNogueira, Mario
dc.contributor.authorClarizia, Gabriela
dc.contributor.authorOngaro, Paula
dc.contributor.authorDurao, Marcelino Souza [UNIFESP]
dc.contributor.authorPacheco-Silva, Alvaro [UNIFESP]
dc.coverageHoboken
dc.date.accessioned2020-07-02T18:52:11Z
dc.date.available2020-07-02T18:52:11Z
dc.date.issued2018
dc.description.abstractDelayed graft function (DGF) is very high in our center (70%-80%), and we usually receive a kidney for transplant after more than 22hours of static cold ischemia time (CIT). Also, there is an inadequate care of the donors, contributing to a high rate of DGF. We decided to test whether machine perfusion (MP) after a CIT improved the outcome of our transplant patients. We analyzed the incidence of DGF, its duration, and the length of hospital stay (LOS) in patients who received a kidney preserved with MP after a CIT (hybrid perfusionHP). We included 54 deceased donors kidneys preserved with HP transplanted from Feb/13 to Jul/14, and compared them to 101 kidney transplants preserved by static cold storage (CS) from Nov/08 to May/12. The median pumping time was 11hours. DGF incidence was 61.1% vs 79.2% (P=.02), median DGF duration was 5 vs 11days (P<.001), and median LOS was 13 vs 18days (P<.011), for the HP compared to CS group. The observed reduction of DGF with machine perfusion did not occur in donors over 50years old. In the multivariate analysis, risk factors for DGF, adjusted for CIT, were donor age (OR, 1.04en
dc.description.abstractP=.005) and the absence of use of MP (OR, 1.54en
dc.description.abstractP=.051). In conclusion, the use of HP contributed to faster recovery of renal function and to a shorter length of hospital stay.en
dc.description.affiliationHosp Israelita Albert Einstein, Renal Transplantat Div, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Med Nephrol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Med Nephrol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipPROADI (Projeto de Apoio ao Desenvolvimento Institucional do SUS)
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1111/ctr.13130
dc.identifier.citationClinical Transplantation. Hoboken, v. 32, n. 1, p. -, 2018.
dc.identifier.doi10.1111/ctr.13130
dc.identifier.fileWOS000419778800002.pdf
dc.identifier.issn0902-0063
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53926
dc.identifier.wosWOS:000419778800002
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofClinical Transplantation
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectdelayed graft functionen
dc.subjectkidney (allograft) function/dysfunctionen
dc.subjectorgan perfusion and preservationen
dc.titleImpact of machine perfusion after long static cold storage on delayed graft function incidence and duration and time to hospital dischargeen
dc.typeinfo:eu-repo/semantics/article
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