Optical Coherence Tomography Features Preceding the Onset of Advanced Age-Related Macular Degeneration

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dc.citation.issue9]
dc.citation.volume58]
dc.contributor.authorFerrara, Daniela
dc.contributor.authorSilver, Rachel E.
dc.contributor.authorLouzada, Ricardo N.
dc.contributor.authorNovais, Eduardo A. [UNIFESP]
dc.contributor.authorCollins, Giliann K.
dc.contributor.authorSeddon, Johanna M.
dc.coverageRockville
dc.date.accessioned2020-06-26T16:30:23Z
dc.date.available2020-06-26T16:30:23Z
dc.date.issued2017
dc.description.abstractPURPOSE. Age-related macular degeneration (AMD) is a progressive disease with multifactorial etiology. There is a need to identify clinical features that are harbingers of advanced disease. We evaluated morphologic features of the retina and choroid on optical coherence tomography (OCT) to determine if they predict progression to advanced disease. METHODS. Progressors transitioned from early or intermediate AMD to advanced disease (n = 40 eyes), and were matched on baseline AMD grade and follow-up interval to nonprogressors who did not develop advanced AMD (n = 40 eyes). Features of the neurosensory retina, photoreceptors, retinal pigment epithelium (RPE), and choroid were evaluated. Logistic regression was used to evaluate univariate associations between features and progression to overall advanced AMD, geographic atrophy (GA), and neovascular disease (NV). Multivariate associations based on stepwise regression models were also assessed. RESULTS. Ellipsoid zone disruption was associated with progression to overall advanced AMD and NV (odds ratios [ORs]: 17.9 and 30.6en
dc.description.abstractP < 0.001), with a similar trend observed for GA. Drusenoid RPE detachment, RPE thickening, and retinal pigmentary hyperreflective material were significantly associated with higher risk of progression to advanced AMD (ORs: 5.0-8.5) and NV (ORs: 10.8-17.2). Pigmentary hyperreflective material was associated with progression to GA (OR: 7.5, P = 0.009). Total retinal thickness, pigmentary hyperreflective material, nascent GA features, and choroidal vessel abnormalities were independently associated with progression to advanced AMD in a multivariate stepwise model. CONCLUSIONS. Abnormalities in the photoreceptors, retinal thickness, RPE, and choroid were associated with higher risk of developing advanced AMD. These findings provide insights into disease progression, and may be helpful to identify earlier endpoints for clinical studies.en
dc.description.affiliationHarvard Univ, Sch Med, Dept Ophthalmol, Boston, MA USA
dc.description.affiliationTufts Med Ctr, New England Eye Ctr, Ophthalm Epidemiol & Genet Serv, Boston, MA 02111 USA
dc.description.affiliationUniv Fed Goias, Dept Ophthalmol, Goiania, Go, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Sch Med, Sao Paulo, Brazil
dc.description.affiliationTufts Univ, Sackler Sch Grad Biomed Sci, Boston, MA 02111 USA
dc.description.affiliationTufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Sch Med, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Institutes of Health
dc.description.sponsorshipMassachusetts Lions Eye Research Fund, Inc., New Bedford, MA, USA
dc.description.sponsorshipInternational Retinal Research Foundation, Inc., Birmingham, AL, USA
dc.description.sponsorshipAmerican Macular Degeneration Foundation, Northampton, MA, USA
dc.description.sponsorshipAge-Related Macular Degeneration Research Fund, Ophthalmic Epidemiology and Genetics Service, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA
dc.description.sponsorshipCAPES Foundation, Ministry of Education of Brazil, Brasilia, DF, Brazil
dc.description.sponsorshipIDNational Institutes of Health: R01-EY011309
dc.description.sponsorshipIDMassachusetts Lions Eye Research Fund, Inc., New Bedford, MA, USA
dc.description.sponsorshipIDInternational Retinal Research Foundation, Inc., Birmingham, AL, USA
dc.description.sponsorshipIDAmerican Macular Degeneration Foundation, Northampton, MA, USA
dc.description.sponsorshipIDAge-Related Macular Degeneration Research Fund, Ophthalmic Epidemiology and Genetics Service, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA
dc.description.sponsorshipIDCAPES
dc.format.extent3519-3529
dc.identifierhttp://dx.doi.org/10.1167/iovs.17-21696]
dc.identifier.citationInvestigative Ophthalmology & Visual Science. Rockville, v. 58, n. 9, p. 3519-3529, 2017.
dc.identifier.doi10.1167/iovs.17-21696
dc.identifier.fileWOS000410931200028.pdf
dc.identifier.issn0146-0404
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53512
dc.identifier.wosWOS:000410931200028
dc.language.isoeng
dc.publisherAssoc Research Vision Ophthalmology Inc
dc.relation.ispartofInvestigative Ophthalmology & Visual Science
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectage-related macular degenerationen
dc.subjectchoroidal neovascularizationen
dc.subjectgeographic atrophyen
dc.subjectoptical coherence tomographyen
dc.subjectprogressionen
dc.titleOptical Coherence Tomography Features Preceding the Onset of Advanced Age-Related Macular Degenerationen
dc.typeinfo:eu-repo/semantics/article
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