Corneal graft survival after therapeutic keratoplasty for Acanthamoeba keratitis

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dc.contributor.authorKashiwabuchi, Renata T. [UNIFESP]
dc.contributor.authorFreitas, Denise de [UNIFESP]
dc.contributor.authorAlvarenga, Lenio S. [UNIFESP]
dc.contributor.authorVieira, Luiz [UNIFESP]
dc.contributor.authorContarini, Patricia [UNIFESP]
dc.contributor.authorSato, Elcio [UNIFESP]
dc.contributor.authorForonda, Annette
dc.contributor.authorHofling-Lima, Ana Luisa [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T13:51:38Z
dc.date.available2016-01-24T13:51:38Z
dc.date.issued2008-09-01
dc.description.abstractPurpose: To describe corneal graft survival and visual outcome after therapeutic penetrating keratoplasty in patients with Acanthamoeba keratitis (AK) that is unresponsive to clinical treatment.Methods: Retrospective study. Thirty-two patients with AK who underwent therapeutic penetrating keratoplasty (tPK) from August 1996 to August 2005 were included. Data relating to clinical features, visual acuity, surgical technique, graft survival and complications were collected. Graft survival was evaluated by the Kaplan-Meier method and comparisons were performed using the Log-rank test.Results: Most patients (62.5%) were female. Mean age [+/- standard deviation (SD)] was 35 (+/- 13) years (range 15-68 years). All patients were contact lens wearers. Eighteen patients (56%) presented paralytic mydriasis and glaucoma during the treatment. Thirteen patients (40%) developed glaucoma after surgery; eight of them (61%) required a second PK because of graft failure. of the 32 keratoplasty eyes, 56.2% presented graft failure at any follow-up point. Forty-five per cent of graft failures occurred before the 12 month follow-up, so 55% remained clear in the first year after surgery. Twelve patients underwent a second PK; seven of them failed and 45% were clear at 1 year. Two patients presented graft recurrence of amoebic infection. There was no significant difference in graft survival when eyes with or without mydriasis were compared (P = 0.40). Eyes with glaucoma presented a significantly shorter graft survival (P = 0.01).Conclusion: Penetrating keratoplasty is a treatment option for eyes that are unresponsive to clinical treatment infections. However, graft survival is poor; postoperative glaucoma is frequent and is associated with shorter graft survival.en
dc.description.affiliationUniversidade Federal de São Paulo, BR-04037002 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, BR-05508 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, BR-04037002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent666-669
dc.identifierhttp://dx.doi.org/10.1111/j.1600-0420.2007.01086.x
dc.identifier.citationActa Ophthalmologica. Malden: Wiley-Blackwell, v. 86, n. 6, p. 666-669, 2008.
dc.identifier.doi10.1111/j.1600-0420.2007.01086.x
dc.identifier.issn1755-375X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30866
dc.identifier.wosWOS:000258726900015
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofActa Ophthalmologica
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectAcanthamoeba keratitisen
dc.subjectgraft survivalen
dc.subjectkeratoplastyen
dc.subjectsurvival curveen
dc.titleCorneal graft survival after therapeutic keratoplasty for Acanthamoeba keratitisen
dc.typeinfo:eu-repo/semantics/article
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