The use of low-cost brewery waste product for the production of surfactin as a natural microbial biocide

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dc.citation.issuen. e00537pt_BR
dc.citation.volumev. 28pt_BR
dc.contributor.authorNazareth, Talita Corrêa
dc.contributor.authorZanutto, Conrado Planas
dc.contributor.authorTripathi, Lakshmi
dc.contributor.authorJuma, Abdulaziz
dc.contributor.authorMaass, Danielle [UNIFESP]
dc.contributor.authorSouza, Antônio Augusto Ulson de
dc.contributor.authorSouza, Selene Maria de Arruda Guelli Ulson de
dc.contributor.authorLatteshttp://lattes.cnpq.br/3431482044015696pt_BR
dc.coverage.spatialAmsterdampt_BR
dc.date.accessioned2021-04-07T18:43:38Z
dc.date.available2021-04-07T18:43:38Z
dc.date.issued2020-10-07
dc.description.abstractSurfactin has potential as next generation antibiofilm agent to combat antimicrobial resistance against emerging pathogens. However, the widespread industrial applications of surfactin is hampered by its high production cost. In this work, surfactin was produced from Bacillus subtilis using a low-cost brewery waste as a carbon source. The strain produced 210.11 mg L-1 after 28 h. The antimicrobial activity was observed against all tested strains, achieving complete inhibition for Pseudomonas aeruginosa, at 500 mg mL-1. A growth log reduction of 3.91 was achieved for P. aeruginosa while, Staphylococcus aureus and Staphylococcus epidermidis showed between 1 and 2 log reductions. In the anti-biofilm assays against P. aeruginosa, the co-incubation, anti-adhesive and disruption showed inhibition, where the greatest inhibition was observed in the co-incubation assay (79.80%). This study provides evidence that surfactin produced from a low-cost substrate can be a promising biocide due to its antimicrobial and anti-biofilm abilities against pathogens.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipID#2019/07659-4pt_BR
dc.format.extent1-10pt_BR
dc.identifierhttps://www.sciencedirect.com/science/article/pii/S2215017X20304847pt_BR
dc.identifier.doi10.1016/j.btre.2020.e00537pt_BR
dc.identifier.issn2215-017Xpt_BR
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/60837
dc.languageengpt_BR
dc.publisherElsevierpt_BR
dc.relation.ispartofBiotechnology Reportspt_BR
dc.rightsinfo:eu-repo/semantics/openAccesspt_BR
dc.subjectSurfactinpt_BR
dc.subjectBiosurfactantspt_BR
dc.subjectBrewery wastept_BR
dc.subjectBiofilmpt_BR
dc.subjectAdhesionpt_BR
dc.titleThe use of low-cost brewery waste product for the production of surfactin as a natural microbial biocidept_BR
dc.title.alternativeThe use of low-cost brewery waste product for the production of surfactin as a natural microbial biocidept_BR
dc.typeinfo:eu-repo/semantics/articlept_BR
unifesp.assessoresproreitoriasNão se aplicapt_BR
unifesp.campusInstituto de Ciência e Tecnologia (ICT)pt_BR
unifesp.departamentoCiência e Tecnologiapt_BR
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