Bone Deposition, Bone Resorption, and Osteosarcoma

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dc.contributor.authorToledo, Silvia Regina Caminada de [UNIFESP]
dc.contributor.authorOliveira, Indhira Dias [UNIFESP]
dc.contributor.authorOkamoto, Oswaldo Keith [UNIFESP]
dc.contributor.authorZago, Marco Antonio
dc.contributor.authorAlves, Maria Teresa de Seixas [UNIFESP]
dc.contributor.authorGarcia Filho, Reynaldo Jesus [UNIFESP]
dc.contributor.authorMacedo, Carla Renata Donato Pacheco [UNIFESP]
dc.contributor.authorPetrilli, Antonio Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:05:20Z
dc.date.available2016-01-24T14:05:20Z
dc.date.issued2010-09-01
dc.description.abstractBone deposition and bone resorption are ongoing dynamic processes, constituting bone remodeling. Some bone tumors, such as osteosarcoma (OS), stimulate focal bone deposition. OS is the most common primary bone tumor in children and young adults. A complex network of genes regulates bone remodeling and alterations in its expression levels can influence the genesis and progression of bone diseases, including OS. We hypothesized that the expression profiles of bone remodeling regulator genes would be correlated with OS biology and clinical features. We used real-time PCR to evaluate the mRNA levels of the tartrate-resistant acid phosphatase (ACP5), colony stimulating factor-1 (CSF1R), bone morphogenetic protein 7 (BMP7), collagen, type XI, alpha 2 (COL11A2), and protein tyrosine phosphatases zeta 1 (PTPRZ1) genes, in 30 OS tumor samples and correlated with clinical and histological data. All genes analyzed, except CSF1R, were differentially expressed when compared with normal bone expression profiles. in our results, OS patients with high levels of COL11A2 mRNA showed worse overall (p = 0.041) and event free survival (p = 0.037). Also, a trend for better overall survival was observed in patients with samples showing higher expression of BMP7 (p =0.067). COL11A2 overexpression and BMP7 underexpression could collaborate to OS tumor growth, through its central role in bone remodeling process. (C) 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:1142-1148, 2010en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pediat, Pediat Oncol Grp, GRAACC,Genet Lab, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Morphol & Genet, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Ctr Cell Based Therapy, Ribeirao Preto, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pathol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Orthoped Surg & Traumatol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pediat, Pediat Oncol Grp, GRAACC,Genet Lab, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Morphol & Genet, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pathol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Orthoped Surg & Traumatol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipGRAACC (Grupo de Apoio ao Adolescente e Crianca corn Cancer)
dc.description.sponsorshipIDFAPESP: 04/12150-8
dc.description.sponsorshipIDFAPESP: 07/53869-3
dc.format.extent1142-1148
dc.identifierhttp://dx.doi.org/10.1002/jor.21120
dc.identifier.citationJournal of Orthopaedic Research. Hoboken: John Wiley & Sons Inc, v. 28, n. 9, p. 1142-1148, 2010.
dc.identifier.doi10.1002/jor.21120
dc.identifier.issn0736-0266
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32831
dc.identifier.wosWOS:000280897100005
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Orthopaedic Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectosteosarcomaen
dc.subjectbone remodelingen
dc.subjectBMP7en
dc.subjectCOL11A2en
dc.titleBone Deposition, Bone Resorption, and Osteosarcomaen
dc.typeinfo:eu-repo/semantics/article
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