Association between Diastolic Dysfunction with Inflammation and Oxidative Stress in Females ob/ob Mice

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dc.contributor.authorSartori, Michelle
dc.contributor.authorConti, Filipe F.
dc.contributor.authorDias, Danielle da Silva
dc.contributor.authordos Santos, Fernando
dc.contributor.authorMachi, Jacqueline F.
dc.contributor.authorPalomino, Zaira [UNIFESP]
dc.contributor.authorCasarini, Dulce E. [UNIFESP]
dc.contributor.authorRodrigues, Bruno
dc.contributor.authorde Angelis, Kytia
dc.contributor.authorIrigoyen, Maria-Claudia
dc.date.accessioned2019-08-19T11:49:42Z
dc.date.available2019-08-19T11:49:42Z
dc.date.issued2017
dc.description.abstractObjective: To evaluate autonomic and cardiovascular function, as well as inflammatory and oxidative stress markers in ob/ob female mice. Methods: Metabolic parameters, cardiac function, arterial pressure (AP), autonomic, hormonal, inflammatory, and oxidative stressmarkers were evaluated in 12-weeks female wild-type (WT group) and ob/ob mice (OB group). Results: OB animals showed increased body weight, blood glucose, and triglyceride levels, along with glucose intolerance, when compared to WT animals. Ejection fraction (EF) and AP were similar between groupsen
dc.description.abstracthowever, the OB group presented diastolic dysfunction, as well as an impairment on myocardial performance index. Moreover, the OB group exhibited important autonomic dysfunction and baroreflex sensitivity impairment, when compared to WT group. OB group showed increased Angiotensin II levels in heart and renal tissuesen
dc.description.abstractdecreased adiponectin and increased inflammatory markers in adipose tissue and spleen. Additionally, OB mice presented a higher damage to proteins and lipoperoxidation and lower activity of antioxidant enzymes in kidney and heart. Correlations were found between autonomic dysfunction with angiotensin II and inflammatory mediators, as well as between inflammation and oxidative stress. Conclusions: Our results showed that female adult ob/ob mice presented discrete diastolic dysfunction accompanied by autonomic disorder, which is associated with inflammation and oxidative stress in these animals.en
dc.description.affiliationUniv São Paulo, Fac Med, Heart Inst InCor, Hypertens Unit, São Paulo, Brazil
dc.description.affiliationUniv Nove Julho, Translat Physiol Lab, São Paulo, Brazil
dc.description.affiliationNova Southeastern Univ, Inst Neuro Immune Med, Dept Integrat Immunol Cardiovasc Res, Ft Lauderdale, FL 33314 USA
dc.description.affiliationUniv Fed São Paulo, Dept Med, Nephrol Div, São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Fac Phys Educ, Dept Adapted Phys Act, Campinas, SP, Brazil
dc.description.affiliationUnifespUniv Fed São Paulo, Dept Med, Nephrol Div, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCAPES
dc.description.sponsorshipCNPq
dc.description.sponsorshipFAPESP
dc.description.sponsorshipCNPq Fellowship (CNPq-BPQ)
dc.description.sponsorshipIDCNPq: 457200/2014-6
dc.description.sponsorshipIDCNPq: 401781/2012-7
dc.description.sponsorshipIDCNPq: 479076/2012-0
dc.description.sponsorshipIDCNPq: 563961/2010-4
dc.description.sponsorshipIDFAPESP: 2015/11223-6
dc.description.sponsorshipIDFAPESP: 2011/15828-9
dc.description.sponsorshipIDFAPESP: 2010/17188-4
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3389/fphys.2017.00572
dc.identifier.citationFrontiers In Physiology. Lausanne, v. 8, p. -, 2017.
dc.identifier.doi10.3389/fphys.2017.00572
dc.identifier.fileWOS000408244600001.pdf
dc.identifier.issn1664-042X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/51377
dc.identifier.wosWOS:000408244600001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.rightsAcesso aberto
dc.subjectobesityen
dc.subjectcardiac dysfunctionen
dc.subjectautonomicen
dc.subjectinflammationen
dc.subjectfemaleen
dc.titleAssociation between Diastolic Dysfunction with Inflammation and Oxidative Stress in Females ob/ob Miceen
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