Genetic variability of cyp3a4 in a heterogeneous brazilian population from maranhao

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dc.contributor.authorMonteiro, Sally Cristina Moutinho
dc.contributor.authorSousa, Israel Higino de
dc.contributor.authorBelfort, Ilka Kassandra Pereira
dc.contributor.authorNunes, Jomar Diogo Costa
dc.contributor.authorPenha, Bruna Aparecida Sousa
dc.contributor.authorSantos, Marcelo dos
dc.contributor.authorLouro, Iuri Drumond
dc.contributor.authorSilva, Ismael Dale Cotrim Guerreiro da [UNIFESP]
dc.date.accessioned2019-01-21T10:30:03Z
dc.date.available2019-01-21T10:30:03Z
dc.date.issued2016
dc.description.abstractInter-individual variability in drug metabolism may result in adverse drug responses. Pharmacogenetic studies have shown that polymorphisms in drug metabolizing enzymes may contribute to this variability. Among these enzymes, CYP3A4 is responsible for metabolizing over 50% of the clinically used drugs. The Brazilian population is composed of people with Native American, European, and African ancestries, and is therefore considered as one of the most intermixed populations in the world. A thorough knowledge of the genetic frequencies of CYP3A4 allelic variants is useful for the establishment of better pharmacological therapies therefore, the aim of this study was to describe the polymorphic frequencies for CYP3A4 -392A>G (rs2740574) in a sample population from Maranhao, Brazil. Our results showed that 75.1, 21.9, and 3.0% of the individuals expressed the -392AA, -392AG, and -392GG genotypes, respectively. The -392A and -392G alleles were observed in 86.1 and 13.9% of the population, respectively. Our results reiterate the need for a better understanding of the variations in the genotype and allele frequencies of CYP3A4 -392A>G polymorphisms in various Brazilian regions, in order to elucidate the variability in drug response.en
dc.description.affiliationPrograma de Pós-Graduação em Saúde do Adulto e da Criança, Universidade Federal do Maranhão, São Luís, MA, Brasil
dc.description.affiliationDepartamento de Medicina, Universidade Federal do Rio Grande do Norte, Campus Caicó, Caicó, RN, Brasil
dc.description.affiliationPrograma de Pós-Graduação em Biotecnologia, Universidade Federal do Espírito Santo, Vitória, ES, Brasil
dc.description.affiliationLaboratório de Ginecologia Molecular, Departamento de Ginecologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil
dc.description.affiliationUnifespLaboratório de Ginecologia Molecular, Departamento de Ginecologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt
dc.format.extentUNSP gmr.15017275
dc.identifierhttps://dx.doi.org/10.4238/gmr.15017275
dc.identifier.citationGenetics And Molecular Research. Ribeirao preto, v. 15, n. 1, p. UNSP gmr.15017275, 2016.
dc.identifier.doi10.4238/gmr.15017275
dc.identifier.issn1676-5680
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/49553
dc.identifier.wosWOS:000373880200030
dc.language.isoeng
dc.publisherFunpec-editora
dc.relation.ispartofGenetics And Molecular Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCyp3a4(Star)1ben
dc.subjectPolymorphismen
dc.subjectGenetic Variabilityen
dc.subjectDrug Metabolismen
dc.subjectPharmacogeneticsDrug-Metabolismen
dc.subjectVarianten
dc.titleGenetic variability of cyp3a4 in a heterogeneous brazilian population from maranhaoen
dc.typeinfo:eu-repo/semantics/article
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