Scaling skeletal muscle function to mass in patients with moderate-to-severe COPD

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dc.contributor.authorMalaguti, Carla
dc.contributor.authorNery, Luiz E.
dc.contributor.authorDal Corso, Simone
dc.contributor.authorNapolis, Lara
dc.contributor.authorDe Fuccio, Marcelo Bicalho
dc.contributor.authorLazaretti-Castro, Marise [UNIFESP]
dc.contributor.authorNeder, José Alberto [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUNINOVE
dc.date.accessioned2016-01-24T12:41:33Z
dc.date.available2016-01-24T12:41:33Z
dc.date.issued2006-11-01
dc.description.abstractSkeletal muscle performance and muscle mass are commonly reduced in patients with advanced chronic obstructive pulmonary disease (COPD). It is currently unclear, however, whether negative changes in muscle structure and function are proportionately related to each other in these patients. in a cross-sectional study, 39 patients (post-bronchodilator FEV1 = 49.7 +/- 15.5% pred) and 17 controls were submitted to knee isokinetic dynamometry [peak torque (PT), isometric strength (IS), and total work (TW)] and dual energy X-ray absorptiometry for the evaluation of leg muscle mass (LMM). Muscle function (F) was normalised for LMM by using ratio standards (F center dot LMM-1), power function ratios (F center dot LMM-b, where b is usually not equal 1), and analysis of covariance (ANCOVA). Patients with COPD presented with reduced PT, IS, TW, and LMM as compared to controls: there were significant linear correlations among these variables in both groups (P < 0.05). Ratio standards of PT center dot LMM-1 and TW center dot LMM-1 were, on average, 14% lower in patients than controls (P < 0.01). the coefficients for allometric correction of IS and TW were significantly higher in patients as compared to controls (0.975 vs. 0.603 and 1.471 vs. 0.824, respectively, P < 0.05), i.e. more LMM was needed to generate a given functional output in patients than normal subjects. in addition, adjusted means of muscle function variables by ANCOVA were 11-18% lower for patients than controls with LMM as the covariate (P < 0.05). We conclude that factors other than simple atrophy (i.e. mass-independent mechanisms) might play a role in explaining the COPD-related skeletal muscle dysfunction.en
dc.description.affiliationUniversidade Federal de São Paulo, São Paulo Paulista Sch Med, Dept Med,Div Resp Dis,SEFICE, Dept Med,Pulm Funct & Clin Exercise Physiol Unit, BR-04020050 São Paulo, Brazil
dc.description.affiliationUNINOVE, Div Rehabil, BR-02117010 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, Div Endocrinol, BR-04020050 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, São Paulo Paulista Sch Med, Dept Med,Div Resp Dis,SEFICE, Dept Med,Pulm Funct & Clin Exercise Physiol Unit, BR-04020050 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, Div Endocrinol, BR-04020050 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent482-488
dc.identifierhttp://dx.doi.org/10.1007/s00421-006-0292-8
dc.identifier.citationEuropean Journal of Applied Physiology. New York: Springer, v. 98, n. 5, p. 482-488, 2006.
dc.identifier.doi10.1007/s00421-006-0292-8
dc.identifier.issn1439-6319
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29224
dc.identifier.wosWOS:000242658400006
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofEuropean Journal of Applied Physiology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectmuscleen
dc.subjectscalingen
dc.subjectstrengthen
dc.subjectCOPDen
dc.subjectoxygen consumptionen
dc.titleScaling skeletal muscle function to mass in patients with moderate-to-severe COPDen
dc.typeinfo:eu-repo/semantics/article
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