Fish oil attenuates methylmalonate-induced seizures

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dc.contributor.authorReschke Bandero, Cristina Ruedell
dc.contributor.authorSalvadori, Mirian G. S. S.
dc.contributor.authorGomes, Anajara Teixeira
dc.contributor.authorDal Ri, Nadja M. K.
dc.contributor.authorFurian, Ana Flavia
dc.contributor.authorOliveira, Mauro Schneider
dc.contributor.authorRambo, Leonardo Magno
dc.contributor.authorScorza, Fulvio A. [UNIFESP]
dc.contributor.authorCysneiros, Roberta M.
dc.contributor.authorEmanuelli, Tatiana
dc.contributor.authorMello, Carlos Fernando
dc.contributor.institutionUniversidade Federal de Sergipe (UFS)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Presbiteriana Mackenzie
dc.date.accessioned2016-01-24T14:31:56Z
dc.date.available2016-01-24T14:31:56Z
dc.date.issued2013-07-01
dc.description.abstractMethylmalonic acidemias are inherited metabolic disorders characterized by methylmalonate (MMA) accumulation and neurological dysfunction, including seizures. Dietary fatty acids are known as an important energy source and reduce seizure activity in selected acute animal models. This study investigated whether chronic treatment with fish oil or with oleic acid attenuates MMA-induced seizures and whether maintenance of Na+,K+-ATPase activity was involved in such an effect. Adult male Wistar rats were given fish oil (85 mg/kg), oleic acid (85 mg/kg) or vehicle (0.42% aqueous Cremophor EL (TM), 4 mL/kg/body weight/day), p.o., for 75 days. On the 73th day a cannula was implanted in the right lateral ventricle with electrodes over the parietal cortex for EEG recording. On the 76th day the animals were injected with NaCl (2.5 mu Lmol/2.5 mu L, i.c.v.), or with MMA (2.5 mu mol/2.5 mu L, i.c.v.), and seizure activity was measured by electroencephagraphic (EEG) recording with concomitant behavior monitoring. the effect of prostaglandin E-2 (PGE(2)) on Na+,K+-ATPase activity of slices of cerebral cortex from NaCl-injected animals was determined. Fish oil increased the latency to MMA-induced tonic-clonic seizures, reduced the mean amplitude of ictal EEG recordings, and prevented PGE(2)-induced decrease of Na+,K+-ATPase activity in cortical slices in vitro. Oleic acid decreased mean amplitude of ictal EEG recordings. the results support that fish oil decreases MMA-induced seizures. the decreased sensitivity of Na+,K+-ATPase to the inhibitory effect of PGE(2) in fish oil-treated animals may be related to the currently reported anticonvulsant activity. (C) 2013 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Santa Maria, Programa Posgrad Farmacol, CCS, BR-97105900 Santa Maria, RS, Brazil
dc.description.affiliationUniv Fed Santa Maria, Dept Fisiol & Farmacol, CCS, BR-97105900 Santa Maria, RS, Brazil
dc.description.affiliationUniv Fed Santa Maria, Dept Tecnol & Ciencia Alimentos, CCR, BR-97105900 Santa Maria, RS, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Disciplina Neurol Expt, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniv Presbiteriana Mackenzie, Ctr Ciencias Biol & Saude, Programa Posgrad Disturbios Desenvolvimento, BR-01302907 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Disciplina Neurol Expt, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDCNPq: 476551/2009-9
dc.description.sponsorshipIDCNPq: 552898/2008-2
dc.description.sponsorshipIDCNPq: 141164/2010-7
dc.description.sponsorshipIDCNPq: 150905/2009-2
dc.description.sponsorshipIDCNPq: 301552/2007-0
dc.format.extent69-76
dc.identifierhttp://dx.doi.org/10.1016/j.eplepsyres.2013.01.005
dc.identifier.citationEpilepsy Research. Amsterdam: Elsevier B.V., v. 105, n. 1-2, p. 69-76, 2013.
dc.identifier.doi10.1016/j.eplepsyres.2013.01.005
dc.identifier.issn0920-1211
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36481
dc.identifier.wosWOS:000320737500008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEpilepsy Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSeizureen
dc.subjectMethylmalonateen
dc.subjectFatty aciden
dc.subjectFish oilen
dc.subjectOleic aciden
dc.titleFish oil attenuates methylmalonate-induced seizuresen
dc.typeinfo:eu-repo/semantics/article
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