Ultrastructural evaluation of gingival glycosaminoglycans in ovariectomized rats: Effects of steroid hormone therapy

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dc.contributor.authorCalio, Pedro Luiz [UNIFESP]
dc.contributor.authorSimoes, Ricardo Santos [UNIFESP]
dc.contributor.authorOliveira-Filho, Ricardo Martins
dc.contributor.authorMaciel, Gustavo Arantes Rosa
dc.contributor.authorSimoes, Manuel de Jesus [UNIFESP]
dc.contributor.authorBaracat, Edmund C. [UNIFESP]
dc.contributor.authorSoares, Jose Maria [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T13:49:27Z
dc.date.available2016-01-24T13:49:27Z
dc.date.issued2008-01-01
dc.description.abstractBackground/Aims: To evaluate the behavior of glycosaminoglycans (GAGs) in rat gingiva and the effects of lack of sexual steroids and the hormonal therapy with estrogen and dexamethasone (DEX). Methods: 40 female rats were divided into four groups: GI: animals in permanent estrus; GII: ovariectomized (OVX) animals + vehicle; GIII: OVX animals treated with 17 beta-estradiol benzoate (10 mu g/kg), and GIV: OVX animals treated with 17 beta-estradiol benzoate (10 mu g/kg) + DEX (3 mg/kg). After treatment, the gingiva was removed and its GAGs content was evaluated by electronic microscopy after stained by cuprolinic blue technique. Results: the electron-microscopic data showed that low values of chondroitin sulfate were found in castrated animals (35.05 +/- 3.58%) compared to other groups (GI: 41.17 +/- 1.13; GIII: 48.04 +/- 2.60; GIV: 49.09 +/- 2.68%). in contrast, the amount of dermatan sulfate in GII (57.70 +/- 2.50%) was higher than in the other groups (GI: 46.12 +/- 1.30; GIII: 42.65 +/- 2.98; GIV: 42.68 +/- 5.43%). Conclusions: GAGs may be influenced by estradiol, and DEX did not seem to antagonize the role of estradiol in the GAGs of gingiva. the histotypical structure of gingiva is related to the amount of chondroitin sulfate. Consequently, the estrogen therapy may be important for gingival health. Copyright (C) 2007 S. Karger AG, Basel.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Morphol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Gynecol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Pharmacol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Obstet & Gynecol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Morphol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Gynecol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent12-17
dc.identifierhttp://dx.doi.org/10.1159/000106499
dc.identifier.citationGynecologic and Obstetric Investigation. Basel: Karger, v. 65, n. 1, p. 12-17, 2008.
dc.identifier.doi10.1159/000106499
dc.identifier.issn0378-7346
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30349
dc.identifier.wosWOS:000251661400003
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofGynecologic and Obstetric Investigation
dc.rightsAcesso restrito
dc.rights.licensehttp://www.karger.com/Services/RightsPermissions
dc.subjectestrogen therapyen
dc.subjectgingival glycosaminoglycansen
dc.subjectglycosaminoglycansen
dc.subjecthormonal therapy, dexamethasoneen
dc.subjecthormonal therapy, estrogenen
dc.subjectsteroid hormone therapyen
dc.titleUltrastructural evaluation of gingival glycosaminoglycans in ovariectomized rats: Effects of steroid hormone therapyen
dc.typeArtigo
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