Methane production and small intestinal bacterial overgrowth in children living in a slum

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dc.contributor.authorMello, Carolina Santos [UNIFESP]
dc.contributor.authorTahan, Soraia [UNIFESP]
dc.contributor.authorMelli, Lígia Cristina Fonseca Lahoz [UNIFESP]
dc.contributor.authorRodrigues, Mirian Silva do Carmo [UNIFESP]
dc.contributor.authorMello, Ricardo Martin Pereira de [UNIFESP]
dc.contributor.authorScaletsky, Isabel Cristina Affonso [UNIFESP]
dc.contributor.authorMorais, Mauro Batista de [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCtr Fdn Inst Educ Osasco
dc.date.accessioned2016-01-24T14:28:00Z
dc.date.available2016-01-24T14:28:00Z
dc.date.issued2012-11-07
dc.description.abstractAIM: To analyze small intestinal bacterial overgrowth in school-aged children and the relationship between hydrogen and methane production in breath tests.METHODS: This transversal study included 85 children residing in a slum and 43 children from a private school, all aged between 6 and 10 years, in Osasco, Brazil. for characterization of the groups, data regarding the socioeconomic status and basic housing sanitary conditions were collected. Anthropometric data was obtained in children from both groups. All children completed the hydrogen (H-2) and methane (CH4) breath test in order to assess small intestinal bacterial overgrowth (SIBO). SIBO was diagnosed when there was an increase in H-2 >= 20 ppm or CH4 >= 10 ppm with regard to the fasting value until 60 min after lactulose ingestion.RESULTS: Children from the slum group had worse living conditions and lower nutritional indices than children from the private school. SIBO was found in 30.9% (26/84) of the children from the slum group and in 2.4% (1/41) from the private school group (P = 0.0007). Greater hydrogen production in the small intestine was observed in children from the slum group when compared to children from the private school (P = 0.007). A higher concentration of hydrogen in the small intestine (P < 0.001) and in the colon (P < 0.001) was observed among the children from the slum group with SIBO when compared to children from the slum group without SIBO. Methane production was observed in 63.1% (53/84) of the children from the slum group and in 19.5% (8/41) of the children from the private school group (P < 0.0001). Methane production was observed in 38/58 (65.5%) of the children without SIBO and in 15/26 (57.7%) of the children with SIBO from the slum. Colonic production of hydrogen was lower in methane-producing children (P = 0.017).CONCLUSION: Children who live in inadequate environmental conditions are at risk of bacterial overgrowth and methane production. Hydrogen is a substrate for methane production in the colon. (C) 2012 Baishideng. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Pediat Gastroenterol Div, BR-04039031 São Paulo, Brazil
dc.description.affiliationCtr Fdn Inst Educ Osasco, BR-06020190 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Infectol Div, BR-04025010 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Microbiol Immunol & Parasitol Div, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Pediat Gastroenterol Div, BR-04039031 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Infectol Div, BR-04025010 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Microbiol Immunol & Parasitol Div, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFood and Nutrition Fund-Municipal Health Fund of Osasco, São Paulo, Brazil
dc.format.extent5932-5939
dc.identifierhttp://dx.doi.org/10.3748/wjg.v18.i41.5932
dc.identifier.citationWorld Journal of Gastroenterology. Beijing: Baishideng Publ Grp Co Ltd, v. 18, n. 41, p. 5932-5939, 2012.
dc.identifier.doi10.3748/wjg.v18.i41.5932
dc.identifier.issn1007-9327
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35503
dc.identifier.wosWOS:000311195200013
dc.language.isoeng
dc.publisherBaishideng Publ Grp Co Ltd
dc.relation.ispartofWorld Journal of Gastroenterology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBacterial overgrowthen
dc.subjectBreath testen
dc.subjectChildrenen
dc.subjectColonen
dc.subjectHydrogenen
dc.subjectMethaneen
dc.subjectSmall intestineen
dc.titleMethane production and small intestinal bacterial overgrowth in children living in a slumen
dc.typeinfo:eu-repo/semantics/article
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