Humoral immune response to measles and varicella vaccination in former very low birth weight preterm infants

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dc.citation.issue1
dc.citation.volume22
dc.contributor.authorMariano Ferreira, Carolina Schlindwein
dc.contributor.authorAbrao Aued Perin, Maria Cristina
dc.contributor.authorde Moraes-Pinto, Maria Isabel
dc.contributor.authorSimao-Gurge, Raquel Maria
dc.contributor.authorGoulart, Ana Lucia
dc.contributor.authorWeckx, Lily Yin
dc.contributor.authorNunes dos Santos, Amelia Miyashiro
dc.coverageRio De Janeiro
dc.date.accessioned2020-07-08T13:09:55Z
dc.date.available2020-07-08T13:09:55Z
dc.date.issued2018
dc.description.abstractIntroduction: Immune response to vaccination in infants born prematurely may be lower than in infants born at full-term. Some clinical factors might be associated with humoral immune response. Objectives: The objectives of this study were to compare the immune response to measles and varicella vaccination in infants born prematurely with those born at full-term and to analyze factors associated with measles and varicella antibody levels. Methods: Prospective study including two groups of infants aged 12 months. One group of infants born prematurely with birth-weight <1500 g and who were in follow-up at the outpatient clinic for preterm infants at the institution and other group of infants born at full-term. Infants with malformations, primary immunodeficiency diseases, born to HIV positive mothers or who had received plasma or immunoglobulin transfusions five months before or three weeks after vaccination were excluded. Plasma antibodies were measured by ELISA and factors associated with antibody levels were assessed by linear regression. Results: Sixty-five premature and 56 full-term infants were included. The percentage of immune individuals after vaccination against measles (100% vs. 100%) and varicella (92.5% vs. 93.2%) were similar in both groups, as well as the antibody levels against measles (2.393 vs. 2.412 Ul/mLen
dc.description.abstractp = 0.970) and varicella (0.551 vs. 0.399 UI/mLen
dc.description.abstractp = 0.114). Use of antenatal corticosteroids decreased measles antibody levels whereas breastfeeding for more than six months increased varicella antibody levels. Conclusions: Humoral responses to measles and varicella were similar between infants born prematurely and full-term infants. Measles antibody levels were negatively associated with antenatal corticosteroid useen
dc.description.abstractvaricella antibodies were positively associated with prolonged breastfeeding. (C) 2017 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. This is an open access article under the CC BY-NC-ND license.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Pediat, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 06/51865-8, 09/14351-4
dc.format.extent41-46
dc.identifierhttp://dx.doi.org/10.1016/j.bjid.2017.12.001
dc.identifier.citationBrazilian Journal Of Infectious Diseases. Rio De Janeiro, v. 22, n. 1, p. 41-46, 2018.
dc.identifier.doi10.1016/j.bjid.2017.12.001
dc.identifier.fileWOS000432647100007.pdf
dc.identifier.issn1413-8670
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54300
dc.identifier.wosWOS:000432647100007
dc.language.isoeng
dc.publisherElsevier Brazil
dc.relation.ispartofBrazilian Journal Of Infectious Diseases
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPrematureen
dc.subjectVaccinationen
dc.subjectHumoral immunityen
dc.subjectMeaslesen
dc.subjectVaricellaen
dc.titleHumoral immune response to measles and varicella vaccination in former very low birth weight preterm infantsen
dc.typeinfo:eu-repo/semantics/article
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