Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil

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dc.citation.volume7
dc.contributor.authorWuo-Silva, Raphael [UNIFESP]
dc.contributor.authorFukushiro, Daniela Fukue [UNIFESP]
dc.contributor.authorHollais, André Willian [UNIFESP]
dc.contributor.authorSantos-Baldaia, Renan [UNIFESP]
dc.contributor.authorMari-Kawamoto, Elisa [UNIFESP]
dc.contributor.authorBerro, Laís Fernanda [UNIFESP]
dc.contributor.authorYokoyama, Thais Suemi [UNIFESP]
dc.contributor.authorLopes-Silva, Leonardo Brito [UNIFESP]
dc.contributor.authorBizerra, Carolina Souza [UNIFESP]
dc.contributor.authorProcopio-Souza, Roberta [UNIFESP]
dc.contributor.authorHashiguchi, Debora [UNIFESP]
dc.contributor.authorFigueiredo, Lilian A. [UNIFESP]
dc.contributor.authorCosta, Jose L.
dc.contributor.authorFrussa-Filho, Roberto [UNIFESP]
dc.contributor.authorLongo, Beatriz Monteiro [UNIFESP]
dc.coverageLausanne
dc.date.accessioned2020-07-31T12:47:17Z
dc.date.available2020-07-31T12:47:17Z
dc.date.issued2016
dc.description.abstractThere is substantial controversy about the addictive potential of modafinil, a wake promoting drug used to treat narcolepsy, proposed as pharmacotherapy for cocaine abuse, and used indiscriminately by healthy individuals due to its positive effects on arousal and cognition. The rapid-onset type of behavioral sensitization (i.e., a type of sensitization that develops within a few hours from the drug priming administration) has been emerged as a valuable tool to study binge-like patterns of drug abuse and the neuroplastic changes that occur quickly after drug administration that ultimately lead to drug abuse. Our aim was to investigate the possible development of rapid-onset behavioral sensitization to modafinil and bidirectional rapid-onset cross sensitization with cocaine in male Swiss mice. A priming injection of a high dose of modafinil (64 mg/kg) induced rapid-onset behavioral sensitization to challenge injections of modafinil at the doses of 16, 32, and 64 mg/kg, administered 4 h later. Furthermore, rapid-onset cross-sensitization was developed between modafinil and cocaine (64 mg/kg modafinil and 20 mg/kg cocaine), in a bidirectional way. These results were not due to residual levels of modafinil as the behavioral effects of the priming injection of modafinil were no longer present and modafinil plasma concentration was reduced at 4 h post-administration. Taken together, the present findings provide preclinical evidence that modafinil can be reinforcing per se and can enhance the reinforcing effects of stimulants like cocaine within hours after administration.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Physiol, Lab Neurophysiol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pharmacol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Fac Pharmaceut Sci, Campinas, SP, Brazil
dc.description.affiliationUnifespLaboratory of Neurophysiology, Department of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationUnifespDepartment of Pharmacology, Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationUnifespDepartment of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundo de Auxílio aos Docentes e Alunos (FADA)
dc.description.sponsorshipAssociação Fundo de Incentivo à Psicofarmacologia (AFIP)
dc.description.sponsorshipIDFAPESP: 2014/24277-4
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3389/fphar.2016.00420
dc.identifier.citationFrontiers In Pharmacology. Lausanne, v. 7, p. -, 2016.
dc.identifier.doi10.3389/fphar.2016.00420
dc.identifier.fileWOS000387083100001.pdf
dc.identifier.issn1663-9812
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56722
dc.identifier.wosWOS:000387083100001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Pharmacology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcocaineen
dc.subjectdrug abuseen
dc.subjectmiceen
dc.subjectmodafinilen
dc.subjectopen fielden
dc.subjectrapid-onset behavioral sensitizationen
dc.titleModafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinilen
dc.typeinfo:eu-repo/semantics/article
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