Not All Children with Cystic Fibrosis Have Abnormal Esophageal Neutralization during Chemical Clearance of Acid Reflux

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dc.citation.issue3
dc.citation.volume20
dc.contributor.authorWoodley, Frederick W.
dc.contributor.authorMoore-Clingenpeel, Melissa
dc.contributor.authorMachado, Rodrigo Strehl [UNIFESP]
dc.contributor.authorNemastil, Christopher J.
dc.contributor.authorJadcherla, Sudarshan R.
dc.contributor.authorHayes, Don, Jr.
dc.contributor.authorKopp, Benjamin T.
dc.contributor.authorKaul, Ajay
dc.contributor.authorDi Lorenzo, Carlo
dc.contributor.authorMousa, Hayat
dc.coverageSeoul
dc.date.accessioned2020-08-04T13:40:14Z
dc.date.available2020-08-04T13:40:14Z
dc.date.issued2017
dc.description.abstractPurpose: Acid neutralization during chemical clearance is significantly prolonged in children with cystic fibrosis, compared to symptomatic children without cystic fibrosis. The absence of available reference values impeded identification of abnormal findings within individual patients with and without cystic fibrosis. The present study aimed to test the hypothesis that significantly more children with cystic fibrosis have acid neutralization durations during chemical clearance that fall outside the physiological range. Methods: Published reference value for acid neutralization duration during chemical clearance (determined using combined impedance/pH monitoring) was used to assess esophageal acid neutralization efficiency during chemical clearance in 16 children with cystic fibrosis (3 to< 18 years) and 16 age-matched children without cystic fibrosis. Results: Duration of acid neutralization during chemical clearance exceeded the upper end ofthe physiological range in 9 of 16 (56.3%) children with and in 3 of 16 (18.8%) children without cystic fibrosis (p=0.0412). The likelihood ratio for duration indicated that children with cystic fibrosis are 2.1-times more likely to have abnormal acid neutralization during chemical clearance, and children with abnormal acid neutralization during chemical clearance are 1.5-times more likely to have cystic fibrosis. Conclusion: Significantly more (but not all) children with cystic fibrosis have abnormally prolonged esophageal clearance of acid. Children with cystic fibrosis are more likely to have abnormal acid neutralization during chemical clearance. Additional studies involving larger sample sizes are needed to address the importance of genotype, esophageal motility, composition and volume of saliva, and gastric acidity on acid neutralization efficiency in cystic fibrosis children.en
dc.description.affiliationNationwide Childrens Hosp, Div Gastroenterol Hepatol & Nutr, 700 Childrens Dr, Columbus, OH 43205 USA
dc.description.affiliationOhio State Univ, Coll Med, Dept Pediat, 700 Childrens Dr, Columbus, OH 43205 USA
dc.description.affiliationNationwide Childrens Hosp, Biostat Core, Columbus, OH USA
dc.description.affiliationUniv Fed Sao Paulo, Dept Pediat, Sao Paulo, Brazil
dc.description.affiliationNationwide Childrens Hosp, Div Pulm Med, Columbus, OH USA
dc.description.affiliationNationwide Childrens Hosp, Res Inst & Neonatol, Columbus, OH USA
dc.description.affiliationCincinnati Childrens Hosp Med Ctr, Div Gastroenterol, Cincinnati, OH 45229 USA
dc.description.affiliationOSU Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA
dc.description.affiliationUniv Calif San Diego, Coll Med, Rady Childrens Hosp, Div Gastroenterol, San Diego, CA 92103 USA
dc.description.affiliationUniv Calif San Diego, Coll Med, Dept Pediat, San Diego, CA 92103 USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pediat, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent153-159
dc.identifierhttp://dx.doi.org/10.5223/pghn.2017.20.3.153
dc.identifier.citationPediatric Gastroenterology Hepatology & Nutrition. Seoul, v. 20, n. 3, p. 153-159, 2017.
dc.identifier.doi10.5223/pghn.2017.20.3.153
dc.identifier.fileWOS000418531900003.pdf
dc.identifier.issn2234-8646
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57387
dc.identifier.wosWOS:000418531900003
dc.language.isoeng
dc.publisherKorean Soc Pediatric Gastroenterology & Nutrition
dc.relation.ispartofPediatric Gastroenterology Hepatology & Nutrition
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChemical clearanceen
dc.subjectAcid neutralizationen
dc.subjectImpedanceen
dc.subjectCystic fibrosisen
dc.subjectChilden
dc.titleNot All Children with Cystic Fibrosis Have Abnormal Esophageal Neutralization during Chemical Clearance of Acid Refluxen
dc.typeinfo:eu-repo/semantics/article
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