Evaluation of MCT1, MCT4 and CD147 Genes in Peripheral Blood Cells of Breast Cancer Patients and Their Potential Use as Diagnostic and Prognostic Markers

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dc.citation.issue4
dc.citation.volume18
dc.contributor.authorLuz, Maria Claudia de B.
dc.contributor.authorPerez, Matheus M.
dc.contributor.authorAzzalis, Ligia A. [UNIFESP]
dc.contributor.authorSousa, Luiz Vinicius de A.
dc.contributor.authorAdami, Fernando
dc.contributor.authorFonseca, Fernando L. A. [UNIFESP]
dc.contributor.authorAlves, Beatriz da C. A.
dc.coverageBasel
dc.date.accessioned2020-07-17T14:02:24Z
dc.date.available2020-07-17T14:02:24Z
dc.date.issued2017
dc.description.abstractBackground: Patients with breast cancer-the deadliest cancer among women-are at constant risk of developing metastasis. Oxidative stress and hypoxia are common feature of tumor cells that can proliferate even in a resultant metabolic acidosis. Despite the low extracellular pH, intracellular pH of tumor cells remains relatively normal, or even more alkaline due to the action of a membrane protein family known as monocarboxylate transporters (MCTs). The objective of this study was to verify the diagnostic and prognostic value of MCT1, MCT4 and CD147 in tumor and peripheral blood samples of patients with breast cancer undergoing chemotherapic treatment. Methods: Differential expression of MCT1, MCT4 and CD147 obtained by qPCR was determined by 2(-Delta Delta Cq) method between biological samples (tumor and serial samples of peripheral) of patients (n = 125) and healthy women (n = 25). Results: tumor samples with higher histological grades have shown higher expression of these markersen
dc.description.abstractthis higher expression was also observed in blood samples obtained at diagnosis of patients when compared to healthy women and in patients with positive progression of the disease (metastasis development). Conclusion: markers studied here could be a promising strategy in routine laboratory evaluations as breast cancer diagnosis and prognosis.en
dc.description.affiliationFMABC, Clin Lab, Ave Principe Gales,821, BR-09060650 Santo Andre, SP, Brazil
dc.description.affiliationUNIFESP, Biol Sci Dept, Rua Prof Artur Riedel,275, BR-09972270 Diadema, SP, Brazil
dc.description.affiliationFMABC, Epidemiol Lab & Data Anal, Ave Principe Gales,821, BR-09060650 Santo Andre, SP, Brazil
dc.description.affiliationUnifespUNIFESP, Biol Sci Dept, Rua Prof Artur Riedel,275, BR-09972270 Diadema, SP, Brazi
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo - FAPESP
dc.description.sponsorshipIDFAPESP: 2014/17693-1
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3390/ijms18040170
dc.identifier.citationInternational Journal Of Molecular Sciences. Basel, v. 18, n. 4, p. -, 2017.
dc.identifier.doi10.3390/ijms18040170
dc.identifier.issn1422-0067
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54789
dc.identifier.wosWOS:000402639400001
dc.language.isoeng
dc.publisherMdpi Ag
dc.relation.ispartofInternational Journal Of Molecular Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbiomarkersen
dc.subjectprognosisen
dc.subjectmetastasisen
dc.subjectbreast canceren
dc.subjectmonocarboxylate transporter (MCT)en
dc.subjecthypoxiaen
dc.titleEvaluation of MCT1, MCT4 and CD147 Genes in Peripheral Blood Cells of Breast Cancer Patients and Their Potential Use as Diagnostic and Prognostic Markersen
dc.typeinfo:eu-repo/semantics/article
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