Functional and morphologic evaluation of kidney proximal tubuli and correlation with renal allograft prognosis

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dc.contributor.authorMatos, Ana Cristina Carvalho de [UNIFESP]
dc.contributor.authorCamara, Niels Olsen Saraiva [UNIFESP]
dc.contributor.authorOliveira, Ana Francisca Franco de [UNIFESP]
dc.contributor.authorFranco, Marcello Fabiano de [UNIFESP]
dc.contributor.authorMoura, Luiz Antonio Ribeiro de [UNIFESP]
dc.contributor.authorNishida, Sonia Kiyomi [UNIFESP]
dc.contributor.authorPereira, Aparecido Bernardo [UNIFESP]
dc.contributor.authorPacheco-Silva, Alvaro [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionAlbert Einstein Hosp
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Jose Rosario Vellano
dc.date.accessioned2016-01-24T13:59:36Z
dc.date.available2016-01-24T13:59:36Z
dc.date.issued2010-05-01
dc.description.abstractP>Renal transplant patients with stable graft function and proximal tubular dysfunction (PTD) have an increased risk for chronic allograft nephropathy (CAN). in this study, we investigated the histologic pattern associated with PTD and its correlation with graft outcome. Forty-nine transplant patients with stable graft function were submitted to a biopsy. Simultaneously, urinary retinol-binding protein (uRBP) was measured and creatinine clearance was also determined. Banff's score and semi-quantitative histologic analyses were performed to assess tubulointerstitial alterations. Patients were followed for 24.0 +/- 7.8 months. At biopsy time, mean serum creatinine was 1.43 +/- 0.33 mg/dl. Twelve patients (24.5%) had uRBP >= 1 mg/l, indicating PTD and 67% of biopsies had some degree of tubulointerstitial injury. At the end of the study period, 18 (36.7%) patients had lost renal function. uRBP levels were not associated with morphologic findings of interstitial fibrosis and tubular atrophy (IF/TA), interstitial fibrosis measured by Sirius red or tubulointerstitial damage. However, in multivariate analysis, the only variable associated with the loss of renal function was uRBP level >= 1 mg/l, determining a risk of 5.290 of loss of renal function (P = 0.003). Renal transplant patients who present PTD have functional alteration, which is not associated with morphologic alteration. This functional alteration is associated to progressive decrease in renal function.en
dc.description.affiliationUniversidade Federal de São Paulo, Div Nephrol, Hosp Rim & Hipertensao, Fundacao Oswaldo Ramos, BR-04023900 São Paulo, Brazil
dc.description.affiliationAlbert Einstein Hosp, Renal Transplantat Unit, Inst Israelita Ensino & Pesquisa Albert Einstein, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Immunol, Transplantat Immunobiol Lab, BR-05508 São Paulo, Brazil
dc.description.affiliationUniv Jose Rosario Vellano, UNIFENAS, Renal Transplantat Unit, Alfenas, MG, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Nephrol, Hosp Rim & Hipertensao, Fundacao Oswaldo Ramos, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipRoche Organ Transplantation Research Foundation-ROTRF
dc.format.extent493-499
dc.identifierhttps://dx.doi.org/10.1111/j.1432-2277.2009.01005.x
dc.identifier.citationTransplant International. Malden: Wiley-Blackwell Publishing, Inc, v. 23, n. 5, p. 493-499, 2010.
dc.identifier.doi10.1111/j.1432-2277.2009.01005.x
dc.identifier.issn0934-0874
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/32486
dc.identifier.wosWOS:000276409000012
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofTransplant International
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectChronic allograft nephropathyen
dc.subjectKidney transplantationen
dc.subjectProximal tubular functionen
dc.subjectRetinol-binding proteinen
dc.subjectSurrogate markeren
dc.subjectTubulointerstitial injuryen
dc.titleFunctional and morphologic evaluation of kidney proximal tubuli and correlation with renal allograft prognosisen
dc.typeinfo:eu-repo/semantics/article
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