Increased renal sympathetic nerve activity leads to hypertension and renal dysfunction in offspring from diabetic mothers

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dc.contributor.authorAlmeida Chaves Rodrigues, Aline Fernanda de [UNIFESP]
dc.contributor.authorBrites de Lima, Ingrid Lauren [UNIFESP]
dc.contributor.authorBergamaschi, Cassia Toledo [UNIFESP]
dc.contributor.authorCampos, Ruy Ribeiro [UNIFESP]
dc.contributor.authorHirata, Aparecida Emiko [UNIFESP]
dc.contributor.authorMaria Schoorlemmer, Guus Hermanus [UNIFESP]
dc.contributor.authorGomes, Guiomar Nascimento [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:30:52Z
dc.date.available2016-01-24T14:30:52Z
dc.date.issued2013-01-01
dc.description.abstractRodrigues AF, de Lima IL, Bergamaschi CT, Campos RR, Hirata AE, Schoorlemmer GH, Gomes GN. Increased renal sympathetic nerve activity leads to hypertension and renal dysfunction in offspring from diabetic mothers. Am J Physiol Renal Physiol 304: F189-F197, 2013. First published November 7, 2012; doi:10.1152/ajprenal.00241.2012.-The exposure of the fetus to a hyperglycemic environment promotes the development of hypertension and renal dysfunction in the offspring at adult age. We evaluated the role of renal nerves in the hypertension and renal changes seen in offspring of diabetic rats. Diabetes was induced in female Wistar rats (streptozotocin, 60 mg/kg ip) before mating. Male offspring from control and diabetic dams were studied at an age of 3 mo. Systolic blood pressure measured by tail cuff was increased in offspring of diabetic dams (146 +/- 1.6 mmHg, n = 19, compared with 117 +/- 1.4 mmHg, n = 18, in controls). Renal function, baseline renal sympathetic nerve activity (rSNA), and arterial baroreceptor control of rSNA were analyzed in anesthetized animals. Glomerular filtration rate, fractional sodium excretion, and urine flow were significantly reduced in offspring of diabetic dams. Two weeks after renal denervation, blood pressure and renal function in offspring from diabetic dams were similar to control, suggesting that renal nerves contribute to sodium retention in offspring from diabetic dams. Moreover, basal rSNA was increased in offspring from diabetic dams, and baroreceptor control of rSNA was impaired, with blunted responses to infusion of nitroprusside and phenylephrine. Thus, data from this study indicate that in offspring from diabetic mothers, renal nerves have a clear role in the etiology of hypertension; however, other factors may also contribute to this condition.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Fisiol, Disciplina Fisiol Renal & Termometab, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Fisiol, Disciplina Fisiol Cardiovasc & Resp, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Fisiol, Disciplina Fisiol Renal & Termometab, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Fisiol, Disciplina Fisiol Cardiovasc & Resp, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundacao Apoio a Pesquisa do Estado de São Paulo
dc.description.sponsorshipIDFundacao Apoio a Pesquisa do Estado de São Paulo: FAPESP 2010/51904-9
dc.format.extentF189-F197
dc.identifierhttp://dx.doi.org/10.1152/ajprenal.00241.2012
dc.identifier.citationAmerican Journal of Physiology-renal Physiology. Bethesda: Amer Physiological Soc, v. 304, n. 2, p. F189-F197, 2013.
dc.identifier.doi10.1152/ajprenal.00241.2012
dc.identifier.issn1931-857X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35677
dc.identifier.wosWOS:000313739600006
dc.language.isoeng
dc.publisherAmer Physiological Soc
dc.relation.ispartofAmerican Journal of Physiology-renal Physiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectmaternal diabetesen
dc.subjectdenervationen
dc.subjectrenal baroreflex controlen
dc.titleIncreased renal sympathetic nerve activity leads to hypertension and renal dysfunction in offspring from diabetic mothersen
dc.typeinfo:eu-repo/semantics/article
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