Differentiating cirrhosis and chronic hepatospienic schistosorniasis using MRI

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dc.contributor.authorBezerra, Alexandre Sergio de Araujo [UNIFESP]
dc.contributor.authorD'Ippolito, Giuseppe [UNIFESP]
dc.contributor.authorCaldana, Rogerio Pedreschi [UNIFESP]
dc.contributor.authorLeopoldino, Denise D.
dc.contributor.authorBatista, Giovani Rodrigues [UNIFESP]
dc.contributor.authorBorges, Durval Rosa [UNIFESP]
dc.contributor.authorLopes Filho, Gaspar de Jesus [UNIFESP]
dc.contributor.authorAhmed, Muneeb
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionSARAH Network Hosp Reabilitat
dc.contributor.institutionBeth Israel Deaconess Med Ctr
dc.date.accessioned2016-01-24T13:49:36Z
dc.date.available2016-01-24T13:49:36Z
dc.date.issued2008-03-01
dc.description.abstractOBJECTIVE. the objective of our study was to identify which imaging features may be used to differentiate between cirrhosis and chronic hepatosplenic schistosomiasis and to assess image interpretation agreement for MRI findings.MATERIALS and METHODS. Retrospective review of 27 patients with alcoholic or virus-induced cirrhosis and 24 patients with chronic hepatosplenic schistosorniasis who underwent MRI (1.5 T) of the abdomen was performed. Images were interpreted independently by two radiologists evaluating the following MRI features: hepatic fissure widening, irregularity of hepatic contours, periportal fibrosis, hepatic parenchyma heterogeneity, and splenic siderotic nodules. Left, right, and caudate hepatic lobe measurements were obtained, and the splenic index was measured. the Fisher's exact test, chi-square test, and Student's t test were used to compare both groups, and regression analysis was performed. Observer agreement was measured using kappa and intraclass correlation tests.RESULTS. Periportal fibrosis, heterogeneity of hepatic parenchyma, and splenic siderotic nodules were more frequent in the group with schistosomiasis (p < 0.05), with periportal fibrosis showing the largest difference in presence and distribution (peripheral greater than central). the transverse diameter of the right hepatic lobe, caudate lobe-right lobe ratio, and splenic index were larger in patients with chronic schistosomiasis (P < 0.001). At multiple regression analysis, splenic siderotic nodules, splenic index, and caudate lobe-right lobe ratio were predictive of schistosomiasis. Observer agreement was substantial or almost perfect for almost all variables analyzed (K or r = 0.81-1.00).CONCLUSION. the presence of peripheral periportall fibrosis,heterogeneity of hepatic parenchyma, and splenic siderotic nodules, and the splenic index and caudate lobe-right lobe ratio are useful features for differentiating alcoholic or virus-induced cirrhosis from chronic schistosomiasis using MRI.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Diagnost Imaging, BR-04024002 São Paulo, Brazil
dc.description.affiliationSARAH Network Hosp Reabilitat, Brasilia, DF, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Surg, São Paulo, Brazil
dc.description.affiliationBeth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Diagnost Imaging, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Surg, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extentW201-W207
dc.identifierhttp://dx.doi.org/10.2214/AJR.07.2639
dc.identifier.citationAmerican Journal of Roentgenology. Reston: Amer Roentgen Ray Soc, v. 190, n. 3, p. W201-W207, 2008.
dc.identifier.doi10.2214/AJR.07.2639
dc.identifier.issn0361-803X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30474
dc.identifier.wosWOS:000253421600029
dc.language.isoeng
dc.publisherAmer Roentgen Ray Soc
dc.relation.ispartofAmerican Journal of Roentgenology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcirrhosisen
dc.subjecthepatosplenic schistosomiasisen
dc.subjectliver diseaseen
dc.subjectMRIen
dc.subjectschistosomiasisen
dc.titleDifferentiating cirrhosis and chronic hepatospienic schistosorniasis using MRIen
dc.typeinfo:eu-repo/semantics/article
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