Effect of central hypothyroidism on Doppler-derived myocardial performance index

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dc.contributor.authorDoin, Fabio Luiz Casanova [UNIFESP]
dc.contributor.authorBorges, Mariana da Rosa [UNIFESP]
dc.contributor.authorCampos, Orlando [UNIFESP]
dc.contributor.authorCarvalho, Antonio Carlos de Camargo [UNIFESP]
dc.contributor.authorPaola, Angelo Amato Vincenzo de [UNIFESP]
dc.contributor.authorPaiva, Marcelo Goulart [UNIFESP]
dc.contributor.authorAbucham, Julio [UNIFESP]
dc.contributor.authorMoises, Valdir Ambrósio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:37:11Z
dc.date.available2016-01-24T12:37:11Z
dc.date.issued2004-06-01
dc.description.abstractBackground. Myocardial performance index (MPI) has been used to assess global ventricular function in different types of cardiac disease. Thyroid hormones influence cardiac performance directly and indirectly by changes in peripheral circulation. the aim of this study was to evaluate the possible effect of central hypothyroidism (CH) on MPI.Methods. the study included 28 control subjects and 7 patients with CH without cardiac disease. MPI was defined as the sum of isovolumetric contraction time (ICT) and isovolumetric relaxation time divided by ejection time. Patients were submitted to hormonal therapy with thyroxin and the study was repeated after 35 to 42 days.Results: MPI was significantly higher in patients with CH (0.54 +/- 0.08) than in control subjects (0.40 +/- 0.05) (P =.002). the increase in MPI was caused by the prolongation of ICT without a significant variation of isovolumetric relaxation time and ejection time. After hormonal therapy there was a significant reduction of MPI (0.54 +/- 0.08 vs 0.42 +/- 0.07; P =.028) and ICT.Conclusion: MPI was increased in patients with untreated CH. the increase was related to prolongation of ICT and reverted by hormonal therapy.en
dc.description.affiliationUniversidade Federal de São Paulo, Paulista Sch Med, Div Cardiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Paulista Sch Med, Div Endocrinol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Paulista Sch Med, Div Cardiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Paulista Sch Med, Div Endocrinol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent622-629
dc.identifierhttp://dx.doi.org/10.1016/j.echo.2004.03.010
dc.identifier.citationJournal of the American Society of Echocardiography. St Louis: Mosby, Inc, v. 17, n. 6, p. 622-629, 2004.
dc.identifier.doi10.1016/j.echo.2004.03.010
dc.identifier.issn0894-7317
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27780
dc.identifier.wosWOS:000221846200003
dc.language.isoeng
dc.publisherMosby, Inc
dc.relation.ispartofJournal of the American Society of Echocardiography
dc.rightsAcesso restrito
dc.titleEffect of central hypothyroidism on Doppler-derived myocardial performance indexen
dc.typeArtigo
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