High incidence of tuberculosis in patients treated for hepatitis C chronic infection

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dc.citation.issue2
dc.citation.volume20
dc.contributor.authorde Oliveira Uehara, Silvia Naomi [UNIFESP]
dc.contributor.authorEmori, Christini Takemi [UNIFESP]
dc.contributor.authorPerez, Renata Mello
dc.contributor.authorJacintho Mendes-Correa, Maria Cassia
dc.contributor.authorPaiva Ferreira, Adalgisa de Souza
dc.contributor.authorde Castro Amaral Feldner, Ana Cristina [UNIFESP]
dc.contributor.authorBenedito Silva, Antonio Eduardo [UNIFESP]
dc.contributor.authorCarvalho Filho, Roberto Jose [UNIFESP]
dc.contributor.authorde Souza e Silva, Ivonete Sandra [UNIFESP]
dc.contributor.authorCardoso Gomes Ferraz, Maria Lucia [UNIFESP]
dc.coverageRio De Janeiro
dc.date.accessioned2020-08-21T17:00:05Z
dc.date.available2020-08-21T17:00:05Z
dc.date.issued2016
dc.description.abstractBrazil is one of the 22 countries that concentrates 80% of global tuberculosis cases concomitantly to a large number of hepatitis C carriers and some epidemiological risk scenarios are coincident for both diseases. We analyzed tuberculosis cases that occurred during alpha-interferon-based therapy for hepatitis C in reference centers in Brazil between 2001 and 2012 and reviewed their medical records. Eighteen tuberculosis cases were observed in patients submitted to hepatitis C alpha-interferon-based therapy. All patients were human immunodeficiency virus-negative. Nine patients (50%) had extra-pulmonary tuberculosis; 15 (83%) showed significant liver fibrosis. Hepatitis C treatment was discontinued in 12 patients (67%) due to tuberculosis reactivation and six (33%) had sustained virological response. The majority of patients had a favorable outcome but one died. Considering the evidences of alpha-IFN interference over the containment of Mycobacterium tuberculosis, the immune impairment of cirrhotic patients, the increase of tuberculosis case reports during hepatitis C treatment with atypical and severe presentations and the negative impact on sustained virological response, we think these are strong arguments for latent tuberculosis infection screening before starting alpha-interferon-based therapy for any indication and even to consider IFN-free regimens against hepatitis C when a patient tests positive for latent tuberculosis infection. (C) 2016 Elsevier Editora Ltda.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Div Gastroenterol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Dept Internal Med, Rio de Janeiro, RJ, Brazil
dc.description.affiliationUniv Sao Paulo, Div Infect Dis, BR-09500900 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Maranhao UFMA, Div Gastroenterol, Sao Luis, MA, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Microbiol Immunol & Parasitol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent205-209
dc.identifierhttp://dx.doi.org/10.1016/j.bjid.2015.12.003
dc.identifier.citationBrazilian Journal Of Infectious Diseases. Rio De Janeiro, v. 20, n. 2, p. 205-209, 2016.
dc.identifier.doi10.1016/j.bjid.2015.12.003
dc.identifier.fileS1413-86702016000200205-en.pdf
dc.identifier.issn1413-8670
dc.identifier.scieloS1413-86702016000200205
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57861
dc.identifier.wosWOS:000372813300014
dc.language.isoeng
dc.publisherElsevier Brazil
dc.relation.ispartofBrazilian Journal Of Infectious Diseases
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHepatitis Cen
dc.subjectTuberculosisen
dc.subjectAlpha-interferonen
dc.subjectLatent tuberculosis infectionen
dc.titleHigh incidence of tuberculosis in patients treated for hepatitis C chronic infectionen
dc.typeinfo:eu-repo/semantics/article
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