Safety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsification

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dc.citation.issue3
dc.citation.volume80
dc.contributor.authorVieira, Ibraim Viana [UNIFESP]
dc.contributor.authorBoianovsky, Celso
dc.contributor.authorSaraiva, Thais Jones
dc.contributor.authorde Godoy, Rodolfo Bregion
dc.contributor.authorLake, Jonathan
dc.coverageSao Paulo
dc.date.accessioned2020-07-13T11:53:16Z
dc.date.available2020-07-13T11:53:16Z
dc.date.issued2017
dc.description.abstractPurpose: To evaluate the safety and efficacy of 0.05 mL intracameral injection of moxifloxacin in patients who underwent phacoemulsification and intraocular lens (IOL) implant. Methods: Retrospective study comprising patients who underwent phacoemulsification and IOL implant between January 2009 and December 2013. Patients were divided into two groups. Group A followed standard endophthalmitis prevention protocol and group B followed the same protocol plus intracameral injection of 0.05 mL of moxifloxacin hydrochloride at 5.45 mg/mL, immediately after IOL implant. Results: Medical records from 7,195 eyes of 3,751 patients (median age: 67.8 +/- 8.96, range: 48-83 years, 53.8% female) were evaluated. Group A included 3,515 eyes of 1,838 patients and group B included 3,680 eyes of 1,913 patients. The incidence of endophthalmitis in group A was 0.22% (8: 3,515 eyes) and in group B was 0.03% (1: 3,680 eyes, p= 0.0198, Fischer's exact test). No toxicity or inflammation related to the use of moxifloxacin was observed. Conclusions: There was a 7.3-fold lower ratio of endophthalmitis in the group that received moxifloxacin intracameral injection. This study provides further evidence that moxifloxacin is an effective intracameral prophylactic antibiotic.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Ophthalmol & Visual Sci, Escola Paulista Med, Sao Paulo, SP, Brazil
dc.description.affiliationOftalmed, Brasilia, DF, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ophthalmol & Visual Sci, Escola Paulista Med, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent165-167
dc.identifierhttps://www.scielo.br/scielo.php?pid=S0004-27492017000300165&script=sci_arttext
dc.identifier.citationArquivos Brasileiros De Oftalmologia. Sao Paulo, v. 80, n. 3, p. 165-167, 2017.
dc.identifier.doi10.5935/0004-2749.20170040
dc.identifier.fileS0004-27492017000300165.pdf
dc.identifier.issn0004-2749
dc.identifier.scieloS0004-27492017000300165
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54506
dc.identifier.wosWOS:000408254100006
dc.language.isoeng
dc.publisherConsel Brasil Oftalmologia
dc.relation.ispartofArquivos Brasileiros De Oftalmologia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEndophthalmitisen
dc.subjectCataracten
dc.subjectPhacoemulsificationen
dc.subjectAnti-bacterial agentsen
dc.subjectInjectionsen
dc.subjectAntibiotic prophylaxisen
dc.titleSafety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsificationen
dc.typeinfo:eu-repo/semantics/article
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