Morphological changes in distant muscle fibers following thermal injury in Wistar rats

Página do item simplificado
dc.contributor.authorDe Oliveira, Flavia [UNIFESP]
dc.contributor.authorBevilacqua, Luci Rezende
dc.contributor.authorAnaruma, Carlos Alberto
dc.contributor.authorBoldrini, Silvia de Campos
dc.contributor.authorLiberti, Edson Aparecido
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-06-15T11:14:55Z
dc.date.available2018-06-15T11:14:55Z
dc.date.issued2010-11-01
dc.description.abstractPurpose: Thermal injury causes catabolic processes as the body attempts to repair the damaged area. This study evaluated the effects of a scald injury on the morphology of muscle fibers belonging to a muscle distant from the lesion. Methods: Thirty Wistar rats were divided into control (C) and scalded (S) groups. Group S was scalded over 45% of the body surface, standardized by body weight. Rats in both groups were euthanized at four, seven and 14 days following the injury. The middle portions of the medial gastrocnemius muscles were sectioned, stained with hematoxylin and eosin and Picrosirius, and submitted to histological analysis. Results: Control group sections exhibited equidistantly distributed polygonal muscle fibers with peripheral nuclei, characteristic of normal muscle. The injured group sections did not consistently show these characteristics; many fibers in these sections exhibited a rounded contour, variable stain intensities, and greater interfiber distances. A substantially increased amount of connective tissue was also observed on the injured group sections. Conclusion: This experimental model found a morphological change in muscle distant from the site of thermal injury covering 45% of the body surface.en
dc.description.affiliationUNIFESP, Dept Biociencias, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, BR-09500900 Sao Paulo, Brazil
dc.description.affiliationState Univ Sao Paulo UNESP, Dept Biosci, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, ICB, Dept Anat, BR-09500900 Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Lab Funct Anat Appl Clin & Surg, BR-09500900 Sao Paulo, Brazil
dc.description.affiliationUnifespUNIFESP, Dept Biociencias, BR-11060001 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent525-528
dc.identifierhttps://dx.doi.org/10.1590/S0102-86502010000600012
dc.identifier.citationActa Cirurgica Brasileira. Sao Paulo: Acta Cirurgica Brasileira, v. 25, n. 6, p. 525-528, 2010.
dc.identifier.doi10.1590/S0102-86502010000600012
dc.identifier.fileS0102-86502010000600012.pdf
dc.identifier.issn0102-8650
dc.identifier.scieloS0102-86502010000600012
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/41980
dc.identifier.wosWOS:000284779000012
dc.language.isoeng
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMorphologyen
dc.subjectMuscle Fibers, Skeletalen
dc.subjectConnective Tissueen
dc.subjectBurnsen
dc.subjectRatsen
dc.titleMorphological changes in distant muscle fibers following thermal injury in Wistar ratsen
dc.title.alternativeAlterações morfológicas das fibras musculares de um músculo distante da lesão térmica em ratos Wistarpt
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
ISS - Artigos