Randomized Trial of Machine Perfusion Versus Cold Storage in Recipients of Deceased Donor Kidney Transplants With High Incidence of Delayed Graft Function

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dc.citation.issue5
dc.citation.volume3
dc.contributor.authorTedesco-Silva Junior, Helio [UNIFESP]
dc.contributor.authorMello Offerni, Juliano Chrystian
dc.contributor.authorCarneiro, Vanessa Ayres
dc.contributor.authorde Paula, Mayara Ivani [UNIFESP]
dc.contributor.authorNeto, Elias David
dc.contributor.authorCarvalhinho Lemos, Francine Brambate
dc.contributor.authorRequiao Moura, Lucio Roberto
dc.contributor.authorPacheco e Silva Filho, Alvaro
dc.contributor.authorde Morais Cunha, Mirian de Fatima
dc.contributor.authorda Silva, Erica Francisco
dc.contributor.authorMiorin, Luiz Antonio
dc.contributor.authorDemetrio, Daniela Priscila
dc.contributor.authorLuconi, Paulo Sergio
dc.contributor.authorda Silva Luconi, Waldere Tania
dc.contributor.authorBobbio, Savina Adriana
dc.contributor.authorKuschnaroff, Liz Milstein
dc.contributor.authorNoronha, Irene Lourdes
dc.contributor.authorBraga, Sibele Lessa
dc.contributor.authorBarsante, Renata Cristina
dc.contributor.authorMendes Moreira, Joao Cezar
dc.contributor.authorMaximina Fernandes-Charpiot, Ida Maria
dc.contributor.authorAbbud-Filho, Mario
dc.contributor.authorModelli de Andrade, Luis Gustavo
dc.contributor.authorGarcia, Paula Dalsoglio
dc.contributor.authorSantamaria Saber, Luciana Tanajura
dc.contributor.authorLaurindo, Alan Fernandes
dc.contributor.authorChocair, Pedro Renato
dc.contributor.authorCuvello Neto, Americo Lourenco
dc.contributor.authorZanocco, Juliana Aparecida
dc.contributor.authorde Almeida Soares Filho, Antonio Jose Duboc
dc.contributor.authorAguiar, Wilson Ferreira [UNIFESP]
dc.contributor.authorPestana, Jose Medina [UNIFESP]
dc.coveragePhiladelphia
dc.date.accessioned2020-07-13T11:53:20Z
dc.date.available2020-07-13T11:53:20Z
dc.date.issued2017
dc.description.abstractBackground. This study compared the use of static cold storage versus continuous hypothermic machine perfusion in a cohort of kidney transplant recipients at high risk for delayed graft function (DGF). Methods. In this national, multicenter, and controlled trial, 80 pairs of kidneys recovered from brain-dead deceased donors were randomized to cold storage or machine perfusion, transplanted, and followed up for 12 months. The primary endpoint was the incidence of DGF. Secondary endpoints included the duration of DGF, hospital stay, primary nonfunction, estimated glomerular filtration rate, acute rejection, and allograft and patient survivals. Results. Mean cold ischemia time was high but not different between the 2 groups (25.6 +/- 6.6 hours vs 25.05 +/- 6.3 hours, 0.937). The incidence of DGF was lower in the machine perfusion compared with cold storage group (61% vs. 45%, P = 0.031). Machine perfusion was independently associated with a reduced risk of DGF (odds ratio, 0.49en
dc.description.abstract95% confidence interval, 0.26-0.95). Mean estimated glomerular filtration rate tended to be higher at day 28 (40.6 +/- 19.9 mL/min per 1.73 m(2) vs 49.0 +/- 26.9 mL/min per 1.73 m(2)en
dc.description.abstractP = 0.262) and 1 year (48.3 +/- 19.8 mL/min per 1.73 m2 vs 54.4 +/- 28.6 mL/min per 1.73 m(2)en
dc.description.abstractP = 0.201) in the machine perfusion group. No differences in the incidence of acute rejection, primary nonfunction (0% vs 2.5%), graft loss (7.5% vs 10%), or death (8.8% vs 6.3%) were observed. Conclusions. In this cohort of recipients of deceased donor kidneys with high mean cold ischemia time and high incidence of DGF, the use of continuous machine perfusion was associated with a reduced risk of DGF compared with the traditional cold storage preservation method.en
dc.description.affiliationUniv Fed Sao Paulo, Hosp Rim, Sao Paulo, SP, Brazil
dc.description.affiliationOrg Procura Orgaos, Escola Paulista Med, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Med, Hosp Clin, Sao Paulo, SP, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Kidney Transplant Unit, Sao Paulo, SP, Brazil
dc.description.affiliationHosp Samaritano, Sao Paulo, SP, Brazil
dc.description.affiliationSanta Casa Sao Paulo, Sao Paulo, SP, Brazil
dc.description.affiliationHosp Bandeirantes, Sao Paulo, SP, Brazil
dc.description.affiliationHosp Servidor Publ Estadual, Sao Paulo, SP, Brazil
dc.description.affiliationHosp Beneficencia Portuguesa, Sao Paulo, SP, Brazil
dc.description.affiliationHosp Dante Pazzanese, Sao Paulo, SP, Brazil
dc.description.affiliationHosp Base Sao Jose do Rio Preto, Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Dept Internal Med, Rubiao Jr S-N, Sao Paulo, Brazil
dc.description.affiliationSanta Casa Ribeirao Preto, Ribeirao Preto, SP, Brazil
dc.description.affiliationHosp Alemao Oswaldo Cruz, Sao Paulo, SP, Brazil
dc.description.affiliationHosp Santa Marcelina, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Hosp Rim, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1097/TXD.0000000000000672
dc.identifier.citationTransplantation Direct. Philadelphia, v. 3, n. 5, p. -, 2017.
dc.identifier.doi10.1097/TXD.0000000000000672
dc.identifier.fileWOS000400508600006.pdf
dc.identifier.issn2373-8731
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54546
dc.identifier.wosWOS:000400508600006
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofTransplantation Direct
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleRandomized Trial of Machine Perfusion Versus Cold Storage in Recipients of Deceased Donor Kidney Transplants With High Incidence of Delayed Graft Functionen
dc.typeinfo:eu-repo/semantics/article
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