Diurnal variation in the genital reflexes and hormone levels induced by paradoxical sleep deprivation and cocaine in male rats

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dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.authorPapale, Ligia Assumpção [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:37:23Z
dc.date.available2016-01-24T12:37:23Z
dc.date.issued2004-09-30
dc.description.abstractThe purpose was to ascertain whether the genital reflexes induced by paradoxical sleep deprivation (PSD) in male rats show diurnal variation, and whether the hormonal rhythm of testosterone and progesterone is involved in these behaviors. Genital reflexes (penile erection - PE, and ejaculation - EJ) and hormone levels were assessed during a 24 h period at four testing times (0900, 1600, 2 100 and 0400 h) in PSD rats injected with saline or cocaine. Results indicated that PE in PSD rats given saline or cocaine did not show diurnal variation while EJ responses were significantly reduced at 0400 h in the PSD-cocaine group. the home-cage control group testosterone concentrations were lower at 1600, 2100 and 0400 h than at 0900 h. At 0900 h, testosterone levels were significantly lower in the PSD groups than in the control group. in contrast, progesterone levels were significantly higher in PSD groups in relation to the control group at the four testing times. Thus, we observed strong diurnal variation in testosterone and progesterone in control rats whereas only EJ responses in PSD-cocaine seemed to be influenced by the time of day. These results suggest that progesterone may influence the modulation of male genital reflexes displayed by sleep-deprived rats. (C) 2004 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Psychobiol, BR-04024002 São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Psychobiol, BR-04024002 São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent215-220
dc.identifierhttps://dx.doi.org/10.1016/j.brainresbull.2004.07.007
dc.identifier.citationBrain Research Bulletin. Oxford: Pergamon-Elsevier B.V., v. 64, n. 3, p. 215-220, 2004.
dc.identifier.doi10.1016/j.brainresbull.2004.07.007
dc.identifier.issn0361-9230
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/27943
dc.identifier.wosWOS:000224523200003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research Bulletin
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSleepen
dc.subjectDrug of abuseen
dc.subjectSexual behavioren
dc.subjectTestosteroneen
dc.subjectProgesteroneen
dc.titleDiurnal variation in the genital reflexes and hormone levels induced by paradoxical sleep deprivation and cocaine in male ratsen
dc.typeinfo:eu-repo/semantics/article
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