Rate of tuberculosis infection in children and adolescents with household contact with adults with active pulmonary tuberculosis as assessed by tuberculin skin test and interferon-gamma release assays

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dc.citation.issue4
dc.citation.volume144
dc.contributor.authorFerrarini, M. A. G. [UNIFESP]
dc.contributor.authorSpina, F. G. [UNIFESP]
dc.contributor.authorWeckx, L. Y. [UNIFESP]
dc.contributor.authorLederman, H. M. [UNIFESP]
dc.contributor.authorDe Moraes-Pinto, M. I. [UNIFESP]
dc.coverageNew York
dc.date.accessioned2020-08-21T17:00:19Z
dc.date.available2020-08-21T17:00:19Z
dc.date.issued2016
dc.description.abstractTuberculosis (TB) infection was evaluated in Brazilian immunocompetent children and adolescents exposed and unexposed (control group) to adults with active pulmonary TB. Both groups were analysed by clinical and radiological assessment, TST, QFT-IT and T-SPOT. TB. The three tests were repeated after 8 weeks in the TB-exposed group if results were initially negative. Individuals with latent tuberculosis infection (LTBI) were treated and tests were repeated after treatment. Fifty-nine TB-exposed and 42 controls were evaluated. Rate of infection was 69.5% and 9.5% for the exposed and control groups, respectively. The exposed group infection rate was 61% assessed by TST, 57.6% by T-SPOT. TB, and 59.3%, by QFT-IT. No active TB was diagnosed. Agreement between the three tests was 83.1% and 92.8% in the exposed and control groups, respectively. In the exposed group, T-SPOT. TB added four TB diagnoses [16%, 95% confidence interval (CI) 1.6-30.4] and QFT-IT added three TB diagnoses (12%, 95% CI 0-24.7) in 25 individuals with negative tuberculin skin test (TST). Risk factors associated to TB infection were contact with an adult with active TB [0-60 days: odds ratio (OR) 6.9; >60 days: OR 27.0] and sleeping in the same room as an adult with active TB (OR 5.2). In Brazilian immunocompetent children and adolescents, TST had a similar performance to interferon-gamma release assays and detected a high rate of LTBI.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Pediat, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Diagnost Imaging, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pediat, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Diagnost Imaging, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Brazil
dc.description.sponsorshipIDFAPESP: 2009/07603-7
dc.format.extent712-723
dc.identifierhttp://dx.doi.org/10.1017/S0950268815001727
dc.identifier.citationEpidemiology And Infection. New York, v. 144, n. 4, p. 712-723, 2016.
dc.identifier.doi10.1017/S0950268815001727
dc.identifier.issn0950-2688
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57937
dc.identifier.wosWOS:000369712100007
dc.language.isoeng
dc.publisherCambridge Univ Press
dc.relation.ispartofEpidemiology And Infection
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdolescentsen
dc.subjectBCGen
dc.subjectChildrenen
dc.subjectIGRAen
dc.subjectlatent tuberculosis infectionen
dc.subjectTSTen
dc.titleRate of tuberculosis infection in children and adolescents with household contact with adults with active pulmonary tuberculosis as assessed by tuberculin skin test and interferon-gamma release assaysen
dc.typeinfo:eu-repo/semantics/article
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