Cut-off values of waist circumference to predict metabolic syndrome in obese adolescents

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dc.contributor.authorMasquio, Deborah Cristina Landi [UNIFESP]
dc.contributor.authorPiano, Aline de [UNIFESP]
dc.contributor.authorCampos, Raquel Munhoz da Silveira [UNIFESP]
dc.contributor.authorSanches, Priscila de Lima [UNIFESP]
dc.contributor.authorCorgosinho, Flavia Campos [UNIFESP]
dc.contributor.authorCaranti, Danielle Arisa [UNIFESP]
dc.contributor.authorTock, Lian
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorDâmaso, Ana Raimunda [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionWeight Sci
dc.date.accessioned2016-01-24T14:40:17Z
dc.date.available2016-01-24T14:40:17Z
dc.date.issued2015-04-01
dc.description.abstractIntroduction: Metabolic syndrome (MetS) is a constellation of metabolic alterations related to abdominal obesity, inflammation and insulin resistance, which increase cardiovascular disease and mortality. the aims of the present study were to identify the prevalence of comorbidities and altered parameters in obese adolescents with and without MetS, and determine cut-off points of waist circumference to predict MetS.Methods: 195 obese adolescents were recruited and divided according to MetS diagnosis based on IDF criteria. Blood analyses of glucose, lipids, liver enzymes, adiponectin and leptin were measured. Insulin resistance was assessed by HOMA-IR, QUICK' and HOMA-AD. Visceral, subcutaneous and hepatic fat were ultrasonography obtained. Body composition was estimated by BOD POD system.Results: We observed a prevalence of 25% of MetS (n=50). the MetS group presented significantly higher body mass, BlVH, body fat (kg), free-fat mass (kg), waist circumference, visceral fat, glucose, insulin, insulin resistance, total-cholesterol, LDL-c, VLDL-c, triglycerides, liver enzymes, blood pressure and non-alcoholic fatty liver disease (NAFLD). Significant lower QUICKI and adiponectin were noted in MetS group. MetS girls presented significantly higher leptin/adiponectin ratio compared to Non-MetS girls. Cut-off points of 111.5 cm for boys and 104.6 cm for girls of waist circumference were suggested to predict metabolic syndrome. Moreover, waist circumference was positively correlated with visceral fat and the number of metabolic syndrome parameters.Conclusion: MetS group presented significantly higher metabolic alterations and inflammation compared to Non-MetS group. Waist circumference is considered an anthropometric measure predictor of metabolic syndrome in obese adolescents, being useful in clinical practice.en
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Postgrad Program Nutr, São Paulo, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Post Grad Program Interdisciplinary Hlth Sci, Santos, SP, Brazil
dc.description.affiliationWeight Sci, São Paulo, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Psychobiol, São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Postgrad Program Nutr, São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Post Grad Program Interdisciplinary Hlth Sci, Santos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Psychobiol, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipUNIFESP
dc.description.sponsorshipAFIP
dc.description.sponsorshipCEPE
dc.description.sponsorshipCEMSA
dc.description.sponsorshipIDCNPq: 141533/2012-9
dc.description.sponsorshipIDCAPES: AUX-PE-PNPD 2566/2011
dc.description.sponsorshipIDFAPESP: 2011/50356-0
dc.description.sponsorshipIDFAPESP: 2011/50414-0
dc.description.sponsorshipIDFAPESP: 2013/ 041364
dc.format.extent1540-1550
dc.identifierhttps://dx.doi.org/10.3305/nh.2015.31.4.8442
dc.identifier.citationNutricion Hospitalaria. Madrid: Aula Medica Ediciones, v. 31, n. 4, p. 1540-1550, 2015.
dc.identifier.doi10.3305/nh.2015.31.4.8442
dc.identifier.fileWOS000352928200012.pdf
dc.identifier.issn0212-1611
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/38922
dc.identifier.wosWOS:000352928200012
dc.language.isoeng
dc.publisherAula Medica Ediciones
dc.relation.ispartofNutricion Hospitalaria
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMetabolic syndromeen
dc.subjectCut off pointen
dc.subjectWaist circumferenceen
dc.subjectNon-alcoholic fatty liver disease and inflammationen
dc.titleCut-off values of waist circumference to predict metabolic syndrome in obese adolescentsen
dc.title.alternativeLos valores de corte de circunferencia de cintura para predecir el síndrome metabólico en adolescentes obesoses
dc.typeinfo:eu-repo/semantics/article
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