Temporal modifications in bone following spinal cord injury in rats

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dc.contributor.authorMedalha, Carla Christina [UNIFESP]
dc.contributor.authorAmorim, Beatriz Oliveira [UNIFESP]
dc.contributor.authorFernandes, Kelly Rossetti [UNIFESP]
dc.contributor.authorPereira, Rosa Maria
dc.contributor.authorRenno, Ana Claudia Muniz [UNIFESP]
dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:28:04Z
dc.date.available2016-01-24T14:28:04Z
dc.date.issued2012-12-01
dc.description.abstractIntroduction: the aim of this study was to investigate the temporal modifications in bone mass, bone biomechanical properties and bone morphology in spinal cord injured rats 2, 4 and 6 weeks after a transection.Material and methods: Control animals were randomly distributed into four groups (n = 10 each group): control group (CG) - control animals sacrificed immediately after surgery; spinal cord-injured 2 weeks (2W) - spinal cord-injured animals sacrificed 2 weeks after surgery; spinal cord-injured 4 weeks (4W) - spinal cord-injured animals sacrificed 4 weeks after surgery; spinal cord-injured 6 weeks (6W) - spinal cord-injured animals sacrificed 6 weeks after surgery.Results: Biomechanical properties of the right tibia were determined by a threepoint bending test and injured animals showed a statistically significant decrease in maximal load compared to control animals. the right femur was used for densitometric analysis and bone mineral content of the animals sacrificed 4 and 6 weeks after surgery was significantly higher compared to the control animals and animals sacrificed 2 weeks after surgery. Histopathological and morphological analysis of tibiae revealed intense resorptive areas in the group 2 weeks after injury only.Conclusions: the results of this study show that this rat model is a valuable tool to investigate bone remodeling processes specifically associated with SCI. Taken together, our results suggest that spinal cord injury induced bone loss within 2 weeks after injury in rats.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biosci, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Div Rheumatol, BR-05508 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biosci, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent1102-1107
dc.identifierhttps://doi.org/10.5114/aoms.2012.32424
dc.identifier.citationArchives of Medical Science. Poznan: Termedia Publishing House Ltd, v. 8, n. 6, p. 1102-1107, 2012.
dc.identifier.doi10.5114/aoms.2012.32424
dc.identifier.issn1734-1922
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/35539
dc.identifier.wosWOS:000312926600024
dc.language.isoeng
dc.publisherTermedia Publishing House Ltd
dc.relation.ispartofArchives of Medical Science
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRaten
dc.subjectSpinal cord injuryen
dc.subjectBone lossen
dc.titleTemporal modifications in bone following spinal cord injury in ratsen
dc.typeinfo:eu-repo/semantics/article
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