Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases

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dc.citation.issue1
dc.citation.volume8
dc.contributor.authordo Amaral, Nayra Soares
dc.contributor.authorMelo, Natalia Cruz e [UNIFESP]
dc.contributor.authorMaia, Beatriz de Melo
dc.contributor.authorRocha, Rafael Malagoli [UNIFESP]
dc.coverageBasel
dc.date.accessioned2020-07-31T12:46:44Z
dc.date.available2020-07-31T12:46:44Z
dc.date.issued2017
dc.description.abstractTobacco and alcohol are the leading environmental risk factors in the development of human diseases, such as cancer, cardiovascular disease, and liver injury. Despite the copious amount of research on this topic, by 2030, 8.3 million deaths are projected to occur worldwide due to tobacco use. The expression of noncoding RNAs, primarily microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), is modulated by tobacco and alcohol consumption. Drinking alcohol and smoking cigarettes can modulate the expression of miRNAs and lncRNAs through various signaling pathways, such as apoptosis, angiogenesis, and inflammatory pathways-primarily interleukin 6 (IL-6)/signal transducer and activator of transcription 3 (STAT3), which seems to play a major role in the development of diseases associated with these risk factors. Since they may be predictive and prognostic biomarkers, they can be used both as predictors of the response to therapy and as a targeted therapy. Further, circulating miRNAs might be valuable noninvasive tools that can be used to examine diseases that are related to the use of tobacco and alcohol. This review discusses the function of noncoding RNAs in cancer and other human tobacco- and alcohol-associated diseases.en
dc.description.affiliationAC Camargo Canc Ctr, Mol Morphol Lab, BR-01508010 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Gynecol, Mol Gynecol Lab, BR-04039032 Sao Paulo, Brazil
dc.description.affiliationUnifespMolecular Gynecology Laboratory, Gynecologic Department, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDFAPESP: 2014/03021-1
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3390/genes8010006
dc.identifier.citationGenes. Basel, v. 8, n. 1, p. -, 2017.
dc.identifier.doi10.3390/genes8010006
dc.identifier.issn2073-4425
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56329
dc.identifier.wosWOS:000399057100006
dc.language.isoeng
dc.publisherMdpi Ag
dc.relation.ispartofGenes
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectnoncoding RNAsen
dc.subjectmicroRNAsen
dc.subjectlong noncoding RNAsen
dc.subjecttobaccoen
dc.subjectalcoholen
dc.subjectcanceren
dc.subjectchronic obstructive pulmonary diseaseen
dc.subjectcardiovascular diseasesen
dc.titleNoncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseasesen
dc.typeinfo:eu-repo/semantics/article
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