High-fat diet and glucocorticoid treatment cause hyperglycemia associated with adiponectin receptor alterations

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dc.contributor.authorOliveira, Cristiane de [UNIFESP]
dc.contributor.authorMattos, Ana Barbosa Marcondes de [UNIFESP]
dc.contributor.authorBiz, Carolina [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorRibeiro, Eliane Beraldi [UNIFESP]
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:06:03Z
dc.date.available2016-01-24T14:06:03Z
dc.date.issued2011-01-18
dc.description.abstractBackground: Adiponectin is the most abundant plasma protein synthesized for the most part in adipose tissue, and it is an insulin-sensitive hormone, playing a central role in glucose and lipid metabolism. in addition, it increases fatty acid oxidation in the muscle and potentiates insulin inhibition of hepatic gluconeogenesis. Two adiponectin receptors have been identified: AdipoR1 is the major receptor expressed in skeletal muscle, whereas AdipoR2 is mainly expressed in liver. Consumption of high levels of dietary fat is thought to be a major factor in the promotion of obesity and insulin resistance. Excessive levels of cortisol are characterized by the symptoms of abdominal obesity, hypertension, glucose intolerance or diabetes and dyslipidemia; of note, all of these features are shared by the condition of insulin resistance. Although it has been shown that glucocorticoids inhibit adiponectin expression in vitro and in vivo, little is known about the regulation of adiponectin receptors. the link between glucocorticoids and insulin resistance may involve the adiponectin receptors and adrenalectomy might play a role not only in regulate expression and secretion of adiponectin, as well regulate the respective receptors in several tissues.Results: Feeding of a high-fat diet increased serum glucose levels and decreased adiponectin and adipoR2 mRNA expression in subcutaneous and retroperitoneal adipose tissues, respectively. Moreover, it increased both adipoR1 and adipoR2 mRNA levels in muscle and adipoR2 protein levels in liver. Adrenalectomy combined with the synthetic glucocorticoid dexamethasone treatment resulted in increased glucose and insulin levels, decreased serum adiponectin levels, reduced adiponectin mRNA in epididymal adipose tissue, reduction of adipoR2 mRNA by 7-fold in muscle and reduced adipoR1 and adipoR2 protein levels in muscle. Adrenalectomy alone increased adiponectin mRNA expression 3-fold in subcutaneous adipose tissue and reduced adipoR2 mRNA expression 2-fold in liver.Conclusion: Hyperglycemia as a result of a high-fat diet is associated with an increase in the expression of the adiponectin receptors in muscle. An excess of glucocorticoids, rather than their absence, increase glucose and insulin and decrease adiponectin levels.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Fisiol, Disciplina Fisiol Nutr, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Fisiol, Disciplina Fisiol Nutr, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent14
dc.identifierhttps://dx.doi.org/10.1186/1476-511X-10-11
dc.identifier.citationLipids in Health and Disease. London: Biomed Central Ltd, v. 10, 14 p., 2011.
dc.identifier.doi10.1186/1476-511X-10-11
dc.identifier.fileWOS000286838800002.pdf
dc.identifier.issn1476-511X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/33353
dc.identifier.wosWOS:000286838800002
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofLipids in Health and Disease
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleHigh-fat diet and glucocorticoid treatment cause hyperglycemia associated with adiponectin receptor alterationsen
dc.typeinfo:eu-repo/semantics/article
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