Are personality traits of juvenile myoclonic epilepsy related to frontal lobe dysfunctions? A proton MRS study
dc.contributor.author | Araujo Filho, Gerardo Maria de [UNIFESP] | |
dc.contributor.author | Lin, Katia [UNIFESP] | |
dc.contributor.author | Lin, Jaime [UNIFESP] | |
dc.contributor.author | Peruchi, Mirella M. [UNIFESP] | |
dc.contributor.author | Caboclo, Luis Otavio S. F. [UNIFESP] | |
dc.contributor.author | Guaranha, Mirian S. B. [UNIFESP] | |
dc.contributor.author | Guilhoto, Laura M. F. F. [UNIFESP] | |
dc.contributor.author | Carrete Junior, Henrique [UNIFESP] | |
dc.contributor.author | Yacubian, Elza Márcia Targas [UNIFESP] | |
dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
dc.date.accessioned | 2016-01-24T13:52:28Z | |
dc.date.available | 2016-01-24T13:52:28Z | |
dc.date.issued | 2009-05-01 | |
dc.description.abstract | Personality traits characterized by emotional instability and immaturity, unsteadiness, lack of discipline, hedonism, frequent and rapid mood changes, and indifference toward one's disease have been associated with patients who have juvenile myoclonic epilepsy (JME). Literature data demonstrate worse seizure control and more psychosocial dysfunctions among patients with JME who have those traits. in this controlled study we performed a correlation analysis of psychiatric scores with magnetic resonance spectroscopy (MRS) values across JME patients, aiming to verify the existence of a possible relation between frontal lobe dysfunction and the prevalence of personality disorders (PDs) in JME.Sixteen JME patients with cluster B PDs, 41 JME patients without any psychiatric disorder, and 30 healthy controls were submitted to a psychiatric evaluation and to a quantitative multivoxel MRS of thalamus; insula; cingulate gyrus; striatum; and frontal, parietal, and occipital lobes. Groups were homogeneous according to age, gender, and manual dominance. Psychiatric evaluation was performed through the Scheduled Clinical Interview for DSM-IV, Axis I and II (SCID I and II, respectively).A significant reduction of N-acetyl-aspartate over creatinine (NAA/Cr) ratio was observed mainly in the left frontal lobe in the JME and PD group. in addition, a significant increase in the glutamate-glutamine over creatinine GLX/Cr ratio was also observed in this referred region in the same group.These data support the hypothesis that PDs in JME could represent neuronal dysfunction and possibly a more severe form of this epileptic syndrome. | en |
dc.description.affiliation | Universidade Federal de São Paulo, Dept Neurol, São Paulo, Brazil | |
dc.description.affiliation | Universidade Federal de São Paulo, Dept Diagnost Imaging, São Paulo, Brazil | |
dc.description.affiliationUnifesp | Universidade Federal de São Paulo, Dept Neurol, São Paulo, Brazil | |
dc.description.affiliationUnifesp | Universidade Federal de São Paulo, Dept Diagnost Imaging, São Paulo, Brazil | |
dc.description.source | Web of Science | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.format.extent | 1201-1209 | |
dc.identifier | http://dx.doi.org/10.1111/j.1528-1167.2009.02021.x | |
dc.identifier.citation | Epilepsia. Malden: Wiley-Blackwell Publishing, Inc, v. 50, n. 5, p. 1201-1209, 2009. | |
dc.identifier.doi | 10.1111/j.1528-1167.2009.02021.x | |
dc.identifier.issn | 0013-9580 | |
dc.identifier.uri | http://repositorio.unifesp.br/handle/11600/31476 | |
dc.identifier.wos | WOS:000265770000030 | |
dc.language.iso | eng | |
dc.publisher | Wiley-Blackwell | |
dc.relation.ispartof | Epilepsia | |
dc.rights | Acesso aberto | |
dc.rights.license | http://olabout.wiley.com/WileyCDA/Section/id-406071.html | |
dc.subject | Magnetic resonance spectroscopy | en |
dc.subject | Idiopathic generalized epilepsy | en |
dc.subject | Juvenile myoclonic epilepsy | en |
dc.subject | Personality disorders | en |
dc.subject | Frontal lobe dysfunction | en |
dc.subject | Psychiatric disorders | en |
dc.title | Are personality traits of juvenile myoclonic epilepsy related to frontal lobe dysfunctions? A proton MRS study | en |
dc.type | Artigo |