Glucocorticoids are not responsible for paradoxical sleep deprivation-induced memory impairments

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dc.contributor.authorTiba, Paula Ayalko [UNIFESP]
dc.contributor.authorMenezes Oliveira, Maria Gabriela [UNIFESP]
dc.contributor.authorRossi, Vanessa Contatto [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorSuchecki, Deborah [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T12:11:57Z
dc.date.available2018-06-18T12:11:57Z
dc.date.issued2008-04-01
dc.description.abstractStudy Objectives: To evaluate whether paradoxical sleep deprivation-induced memory impairments are due to release of glucocorticoids, by means of corticosterone inhibition with metyrapone.Design: The design was a 2 (Groups [control, paradoxical sleep-deprived]) x 2 (Treatments [vehicle, metyrapone]) study, performed in 2 experiments: Acute treatment (single injection given immediately after 96 hours of sleep deprivation) and chronic treatment (8 injections, twice per day, throughout the sleep-deprivation period). Animals were either paradoxical sleep-deprived or remained in their home cages for 96 hours before training in contextual fear conditioning and received intraperitoneal injections of a corticosterone synthesis inhibitor, metyrapone. Memory performance was tested 24 hours after training.Subjects: Three-month old Wistar male rats.Measurements: Freezing behavior was considered as the conditioning index, and adrenocorticotropic hormone and corticosterone plasma levels were determined from trunk blood of animals sacrificed in different time points. Animals were weighed before and after the paradoxical sleep-deprivation period.Results: Acute metyrapone treatment impaired memory in control animals and did not prevent paradoxical sleep deprivation-induced memory impairment. Likewise, in the chronic treatment, paradoxical sleep-deprived animals did not differ from control rats in their corticosterone or adrenocorticotropic hormone response to training, but still did not learn as well, and did not show any stress responses to the testing. Chronic metyrapone was, however, effective in preventing the weight loss typically observed in paradoxical sleep-deprived animals.Conclusions: Our results suggest that glucocorticoids do not mediate memory impairments but might be responsible for the weight loss induced by paradoxical sleep deprivation.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, BR-04024002 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychobiol, BR-04024002 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent505-515
dc.identifierhttps://doi.org/10.1093/sleep/31.4.505
dc.identifier.citationSleep. Westchester: Amer Acad Sleep Medicine, v. 31, n. 4, p. 505-515, 2008.
dc.identifier.issn0161-8105
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/45603
dc.identifier.wosWOS:000254936400010
dc.language.isoeng
dc.publisherAmer Acad Sleep Medicine
dc.relation.ispartofSleep
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectparadoxical sleep deprivationen
dc.subjectlearningen
dc.subjectmemoryen
dc.subjectmetyraponeen
dc.subjectcontextual fear conditioningen
dc.subjectcorticosteroneen
dc.subjectweight lossen
dc.subjectraten
dc.titleGlucocorticoids are not responsible for paradoxical sleep deprivation-induced memory impairmentsen
dc.typeinfo:eu-repo/semantics/article
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