Verbal fluency facilitated by the cholinergic blocker, scopolamine

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dc.contributor.authorPompeia, S.
dc.contributor.authorRusted, J. M.
dc.contributor.authorCurran, H. V.
dc.contributor.institutionUniv Sussex
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUCL
dc.date.accessioned2016-01-24T12:33:10Z
dc.date.available2016-01-24T12:33:10Z
dc.date.issued2002-01-01
dc.description.abstractThis study was designed to explore putative facilitatory effects of low doses of scopolamine (SP) on phonemic (letter) and semantic (category) verbal fluency. A double-blind, parallel-group design was used with 36 subjects who completed a test battery before and 2 h after 0.6 mg or 1.2 mg of SP or placebo. Fluency measures included total number of words generated, clustering (the production of words within semantic or phonemic subcategories) and switching (the ability to shift efficiently to new subcategories). Low doses of scopolamine increased phonemic fluency, as has been shown previously. Semantic fluency was not increased by SP, although subjects treated with 1.2 mg of SP generated higher-frequency words. SP did not affect clustering or switching. It is suggested that phonemic and semantic fluency reflect distinct cognitive processes. Copyright (C) 2002 John Wiley Sons, Ltd.en
dc.description.affiliationUniv Sussex, Dept Expt Psychol, Falmer BN1 9QG, Sussex, England
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUCL, Dept Psychol, London, England
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent51-59
dc.identifierhttp://dx.doi.org/10.1002/hup.331
dc.identifier.citationHuman Psychopharmacology-clinical and Experimental. Malden: Wiley-Blackwell, v. 17, n. 1, p. 51-59, 2002.
dc.identifier.doi10.1002/hup.331
dc.identifier.issn0885-6222
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26691
dc.identifier.wosWOS:000173604200006
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofHuman Psychopharmacology-clinical and Experimental
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectscopolamineen
dc.subjectanticholinergicen
dc.subjectmuscarinic antagonisten
dc.subjectverbal fluencyen
dc.subjectsemantic memoryen
dc.subjectclusteringen
dc.subjectswitchesen
dc.titleVerbal fluency facilitated by the cholinergic blocker, scopolamineen
dc.typeinfo:eu-repo/semantics/article
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