Antiretroviral drugs saquinavir and ritonavir reduce inhibitory concentration values of itraconazole against Histoplasma capsulatum strains in vitro

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dc.citation.issue2
dc.citation.volume20
dc.contributor.authorNogueira Brilhante, Raimunda Samia
dc.contributor.authorCaetano, Erica Pacheco
dc.contributor.authorRiello, Giovanna Barbosa
dc.contributor.authorde Melo Guedes, Glaucia Morgana
dc.contributor.authorCollares Maia Castelo-Branco, Debora de Souza
dc.contributor.authorBezerra Fechine, Maria Auxiliadora
dc.contributor.authorde Oliveira, Jonathas Sales
dc.contributor.authorde Camargo, Zoilo Pires [UNIFESP]
dc.contributor.authorLima de Mesquita, Jaco Ricarte
dc.contributor.authorMonteiro, Andre Jalles
dc.contributor.authorCordeiro, Rossana de Aguiar
dc.contributor.authorGadelha Rocha, Marcos Fabio
dc.contributor.authorCosta Sidrim, Jose Julio
dc.coverageRio De Janeiro
dc.date.accessioned2020-08-21T17:00:04Z
dc.date.available2020-08-21T17:00:04Z
dc.date.issued2016
dc.description.abstractRecent studies have shown that some drugs that are not routinely used to treat fungal infections have antifungal activity, such as protease inhibitor antiretroviral drugs. This study investigated the in vitro susceptibility of Histoplasma capsulatum var. capsulatum to saquinavir and ritonavir, and its combination with the antifungal itraconazole. The susceptibility assay was performed according to Clinical and Laboratory Standards Institute guidelines. All strains were inhibited by the protease inhibitor antiretroviral drugs. Saquinavir showed minimum inhibitory concentrations ranging from 0.125 to 1 mu g mL(-1) for both phases, and ritonavir presented minimum inhibitory concentrations ranging from 0.0312 to 4 mu g mL(-1) and from 0.0625 to 1 mu g mL(-1) for filamentous and yeast phase, respectively. Concerning the anti fungal itraconazole, the minimum inhibitory concentration values ranged from 0.0019 to 0.125 mu g mL(-1) and from 0.0039 to 0.0312 mu g mL(-1) for the filamentous and yeast phase, respectively. The combination of saquinavir or ritonavir with itraconazole was synergistic against H. capsulatum, with a significant reduction in the minimum inhibitory concentrations of both drugs against the strains (p < 0.05). These data show an important in vitro synergy between protease inhibitors and itraconazole against the fungus H. capsulatum. (C) 2016 Published by Elsevier Editora Ltda.en
dc.description.affiliationUniv Fed Ceara, Postgrad Program Med Microbiol, Specialized Med Mycol Ctr, Fortaleza, CE, Brazil
dc.description.affiliationUniv Fed Ceara, Postgrad Program Med Sci, Fortaleza, CE, Brazil
dc.description.affiliationUniv Estadual Ceara UECE, Postgrad Program Vet Sci, Fortaleza, CE, Brazil
dc.description.affiliationUniv Fed Ceara, Dept Stat & Appl Math, Fortaleza, CE, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Microbiol Immunol & Parasitol, Sao Paulo, SP, Brazil
dc.description.affiliationHosp Sao Jose, Fortaleza, CE, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Microbiol Immunol & Parasitol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCNPq
dc.description.sponsorshipCAPES
dc.description.sponsorshipIDCNPq: 303396/2014-8
dc.description.sponsorshipIDCNPq: 552161/2011-0
dc.description.sponsorshipIDCAPES: AE1 - 0052-000630100/11
dc.format.extent155-159
dc.identifierhttp://dx.doi.org/10.1016/j.bjid.2015.11.003
dc.identifier.citationBrazilian Journal Of Infectious Diseases. Rio De Janeiro, v. 20, n. 2, p. 155-159, 2016.
dc.identifier.doi10.1016/j.bjid.2015.11.003
dc.identifier.fileS1413-86702016000200155-en.pdf
dc.identifier.issn1413-8670
dc.identifier.scieloS1413-86702016000200155
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57860
dc.identifier.wosWOS:000372813300007
dc.language.isoeng
dc.publisherElsevier Brazil
dc.relation.ispartofBrazilian Journal Of Infectious Diseases
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHistoplasma capsulatumen
dc.subjectSaquinaviren
dc.subjectRitonaviren
dc.subjectItraconazoleen
dc.titleAntiretroviral drugs saquinavir and ritonavir reduce inhibitory concentration values of itraconazole against Histoplasma capsulatum strains in vitroen
dc.typeinfo:eu-repo/semantics/article
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