Strategies for Development of Antimalarials Based on Encapsulated Porphyrin Derivatives

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dc.contributor.authorDeda, Daiana Kotra
dc.contributor.authorBudu, Alexandre [UNIFESP]
dc.contributor.authorCruz, Laura Nogueira
dc.contributor.authorAraki, Koiti
dc.contributor.authorGarcia, Celia Regina da Silva
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T11:04:06Z
dc.date.available2018-06-18T11:04:06Z
dc.date.issued2014-01-01
dc.description.abstractDespite the efforts in controlling the parasite and infection, and the significant progress achieved in recent years in its treatment, malaria is still prevalent in many regions and out of control in others. The repertoire of alternatives to fight malaria is being expanded, not only by designing new drugs but also by developing improved drug delivery systems able to enhance the antimalarial efficiency of conventional and new drugs. Among the new drugs that have been investigated, several publications report the use of porphyrin derivatives as antimalarials but their efficiency is contradictory. The low activity of porphyrins seems to be associated with low dispersibility and bioavailability. In this respect, Nanotechnology can provide efficient solutions to enhance bioavailability and delivery of conventional and new antimalarials, in order to assure high enough efficiency levels to inactivate the parasite. Thus, in this review we highlight the use of drug delivery systems for conventional and new antimalarials and we propose the encapsulation of porphyrins as a promising alternative for development of anti-malarial formulations.en
dc.description.affiliationUniv Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biofis, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biociencias, Dept Fisiol, BR-05508 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biofis, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent1055-1071
dc.identifierhttp://dx.doi.org/10.2174/1389557515666150101094829#sthash.z9BJie3w.dpuf
dc.identifier.citationMini-reviews In Medicinal Chemistry. Sharjah: Bentham Science Publ Ltd, v. 14, n. 13, p. 1055-1071, 2014.
dc.identifier.doi10.2174/1389557515666150101094829#sthash.z9BJie3w.dpuf
dc.identifier.issn1389-5575
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44910
dc.identifier.wosWOS:000347919000004
dc.language.isoeng
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofMini-reviews In Medicinal Chemistry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectDrug delivery systemsen
dc.subjectmalariaen
dc.subjectnanotechnologyen
dc.subjectPlasmodium falciparumen
dc.subjectpolymeric particlesen
dc.subjectporphyrinsen
dc.titleStrategies for Development of Antimalarials Based on Encapsulated Porphyrin Derivativesen
dc.typeinfo:eu-repo/semantics/article
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