Correlation between heart rate variability and pulmonary function adjusted by confounding factors in healthy adults

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dc.citation.issue3
dc.citation.volume49
dc.contributor.authorBianchim, Mayara Silveira [UNIFESP]
dc.contributor.authorSperandio, Evandro Fornias [UNIFESP]
dc.contributor.authorMartinhao, Graciana Santos [UNIFESP]
dc.contributor.authorMatheus, Agatha Caveda [UNIFESP]
dc.contributor.authorLauria, Vinicius Tonon [UNIFESP]
dc.contributor.authorSilva, Rodrigo Pereira da [UNIFESP]
dc.contributor.authorSpadari, Regina Celia [UNIFESP]
dc.contributor.authorGagliardi, Antonio Ricardo de Toledo
dc.contributor.authorArantes, Rodolfo Leite
dc.contributor.authorRomiti, Marcello
dc.contributor.authorDourado, Victor Zuniga [UNIFESP]
dc.coverageSao Paulo
dc.date.accessioned2020-08-21T17:00:18Z
dc.date.available2020-08-21T17:00:18Z
dc.date.issued2016
dc.description.abstractThe autonomic nervous system maintains homeostasis, which is the state of balance in the body. That balance can be determined simply and noninvasively by evaluating heart rate variability (HRV). However, independently of autonomic control of the heart, HRV can be influenced by other factors, such as respiratory parameters. Little is known about the relationship between HRV and spirometric indices. In this study, our objective was to determine whether HRV correlates with spirometric indices in adults without cardiopulmonary disease, considering the main confounders (e.g., smoking and physical inactivity). In a sample of 119 asymptomatic adults (age 20-80 years), we evaluated forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1). We evaluated resting HRV indices within a 5-min window in the middle of a 10-min recording period, thereafter analyzing time and frequency domains. To evaluate daily physical activity, we instructed participants to use a triaxial accelerometer for 7 days. Physical inactivity was defined as <150 min/week of moderate to intense physical activity. We found that FVC and FEV1, respectively, correlated significantly with the following aspects of the RR interval: standard deviation of the RR intervals (r= 0.31 and 0.35), low-frequency component (r= 0.38 and 0.40), and Poincare plot SD2 (r= 0.34 and 0.36). Multivariate regression analysis, adjusted for age, sex, smoking, physical inactivity, and cardiovascular risk, identified the SD2 and dyslipidemia as independent predictors of FVC and FEV1 (R-2= 0.125 and 0.180, respectively, for both). We conclude that pulmonary function is influenced by autonomic control of cardiovascular function, independently of the main confounders.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Ciencias Movimento Humano, Lab Epidemiol & Movimento Humano, Santos, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biociencias, Santos, SP, Brazil
dc.description.affiliationAngioCorpore Inst Med Cardiovasc, Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ciencias Movimento Humano, Lab Epidemiol & Movimento Humano, Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biociencias, Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2011/07282-6
dc.format.extent-
dc.identifierhttps://dx.doi.org/10.1590/1414-431X20154435
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Sao Paulo, v. 49, n. 3, p. -, 2016.
dc.identifier.doi10.1590/1414-431X20154435
dc.identifier.fileS0100-879X2016000300702-en.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2016000300702
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57928
dc.identifier.wosWOS:000370521400001
dc.language.isoeng
dc.publisherAssoc Bras Divulg Cientifica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAutonomic nervous systemen
dc.subjectSpirometryen
dc.subjectSmokingen
dc.titleCorrelation between heart rate variability and pulmonary function adjusted by confounding factors in healthy adultsen
dc.typeinfo:eu-repo/semantics/article
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