Anti-beta(2)-glycoprotein i antibodies are highly prevalent in a large number of Brazilian leprosy patients

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dc.contributor.authorRibeiro, Sandra Lucia Euzebio [UNIFESP]
dc.contributor.authorPereira, Helena LĂșcia Alves [UNIFESP]
dc.contributor.authorSilva, Neusa Pereira da [UNIFESP]
dc.contributor.authorSouza, Alexandre Wagner Silva de [UNIFESP]
dc.contributor.authorSato, Emilia Inoue [UNIFESP]
dc.contributor.institutionUniv Fed Amazonas
dc.contributor.institutionUniversidade Federal de SĂŁo Paulo (UNIFESP)
dc.date.accessioned2018-06-15T12:47:30Z
dc.date.available2018-06-15T12:47:30Z
dc.date.issued2011-01-01
dc.description.abstractObjectives: To determine the prevalence of anticardiolipin (aCL) and anti-beta(2)-glycoprotein I (anti-beta(2)GPI) antibodies in leprosy patients, during and after specific multidrug therapy (MDT), and to evaluate a possible association between these antibodies and some clinical characteristics of leprosy, including clinical forms, reactional episodes and treatment.Methods: The study included 158 leprosy patients, 129 gender-and-age matched healthy individuals, and 38 women with primary antiphospholipid syndrome (APS). Clinical and demographic characteristic of leprosy patients were collected, and serum samples, obtained from all participants, were kept frozen at - 20 degrees C. Antibodies were measured either by an in house-developed ELISA (aCL) or by a commercial ELISA (anti-beta(2)GPI).Results and Conclusions: Increased levels of aCL and anti-beta(2)GPI antibodies were found in leprosy patients and in the APS group, however, in contrast to APS, the predominant isotype in leprosy was IgM. The frequency of aCL and anti-beta(2)GPI antibodies was significantly higher in leprosy patients than in healthy individuals (15.8% vs. 3.1%; p < 0.01; 46.2% vs. 9.4%, p < 0.01), respectively. The lepromatous form predominated among aCL positive leprosy patients (p < 0.01). There was no difference in aCL and anti-beta(2)GPI positivity between leprosy patients taking MDT and those completed MDT as cured. Furthermore the duration of discharged period (period between discharge from MDT and the realization of the study) had no effect on anti-beta(2)GPI positivity, and a slight increase in aCL positivity was observed in patients with longer follow up periods (p=0.04), suggesting that the presence of antiphospholipid antibodies (aPL) was not a transient phenomenon. Although aPL in leprosy were frequent and beta(2)GPI-dependent as those found in APS, IgM was the predominant isotype, and there was no association with thrombosis or other APS manifestations.en
dc.description.affiliationUniv Fed Amazonas, Div Rheumatol, Manaus, Amazonas, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Div Rheumatol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Div Rheumatol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent30-37
dc.identifierhttps://www.actareumatologica.pt/article_download.php?id=648
dc.identifier.citationActa Reumatologica Portuguesa. Alges: Medfarma-edicoes Medicas, Lda, v. 36, n. 1, p. 30-37, 2011.
dc.identifier.fileWOS000288828700006.pdf
dc.identifier.issn0303-464X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/42090
dc.identifier.wosWOS:000288828700006
dc.language.isoeng
dc.publisherMedfarma-edicoes Medicas, Lda
dc.relation.ispartofActa Reumatologica Portuguesa
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLeprosyen
dc.subjectAnti-beta(2)-glycoprotein I antibodiesen
dc.subjectAntiphospholipid antibodiesen
dc.subjectAnticardiolipin antibodiesen
dc.subjectAntiphospholipid syndromeen
dc.titleAnti-beta(2)-glycoprotein i antibodies are highly prevalent in a large number of Brazilian leprosy patientsen
dc.typeinfo:eu-repo/semantics/article
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