Ascorbic acid prevents acute myocardial infarction induced by isoproterenol in rats: role of inducible nitric oxide synthase production

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dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.contributor.authorButtros, Juliana Beatriz [UNIFESP]
dc.contributor.authorOshima, Celina Tizuko Fujiyama [UNIFESP]
dc.contributor.authorBergamaschi, Cassia Toledo [UNIFESP]
dc.contributor.authorCampos, Ruy Ribeiro [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:52:23Z
dc.date.available2016-01-24T13:52:23Z
dc.date.issued2009-04-01
dc.description.abstractThe goal of this study was to investigate whether sub-chronic anti-oxidant treatment with ascorbic acid (Vit C) is able to protect the heart against myocardial infarction. the effects of Vit C treatment on the histopatological changes and immunohistochemistry for p53, COX-2 and iNOS were evaluated in rats submitted to acute myocardial infarction induced by isoproterenol (ISO). Male Wistar rats (n = 32) were divided into four groups: group 1, control; group 2, ISO treated; group 3, Vit C treated; group 4, ISO + Vit C treated. An amount of 150 mg/kg of isoproterenol was administered for two consecutive days. the rats were treated with Vit C once a day (150 mg/kg, orally) for seven consecutive days. in the day 5 and 6 the rats from group ISO + Vit C were submitted to acute administration of ISO third minutes after Vit C treatment. the results pointed out that treatment with Vit C showed mild degenerative changes of myocardial tissue in ISO group. Also, the antioxidant was able to decrease the iNOS expression in rats treated with Vit C. Taken together, our results suggest that chronic Vit C administration was able to prevent the myocardial infarction induced by ISO as a result of iNOS downregulation. Certainly, this finding offers new insights into the mechanisms underlying the relation between oxidative stress and cardiac mortality after myocardial infarction.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biosci, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUniv Federal de São Paulo, Dept Pathol, Paulista Med Sch, São Paulo, Brazil
dc.description.affiliationUniv Federal de São Paulo, Dept Physiol, Paulista Med Sch, Div Cardiovasc, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biosci, BR-11060001 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 07/01228-4
dc.format.extent99-105
dc.identifierhttps://dx.doi.org/10.1007/s10735-009-9218-1
dc.identifier.citationJournal of Molecular Histology. Dordrecht: Springer, v. 40, n. 2, p. 99-105, 2009.
dc.identifier.doi10.1007/s10735-009-9218-1
dc.identifier.issn1567-2379
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/31409
dc.identifier.wosWOS:000267784900002
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal of Molecular Histology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectIsoproterenolen
dc.subjectAscorbic aciden
dc.subjectHeart infarctionen
dc.subjectp53en
dc.subjectCOX-2en
dc.subjectiNOSen
dc.subjectRatsen
dc.titleAscorbic acid prevents acute myocardial infarction induced by isoproterenol in rats: role of inducible nitric oxide synthase productionen
dc.typeinfo:eu-repo/semantics/article
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