Application of ductus venosus Doppler velocimetry for the detection of fetal aneuploidy in the first trimester of pregnancy

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dc.contributor.authorMurta, CGV
dc.contributor.authorMoron, A. F.
dc.contributor.authorAvila, MAP
dc.contributor.authorWeiner, C. P.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFed Univ Espirito Santo
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniv Maryland
dc.date.accessioned2016-01-24T12:33:31Z
dc.date.available2016-01-24T12:33:31Z
dc.date.issued2002-09-01
dc.description.abstractObjective: To test the hypothesis the application of ductus venosus Doppler velocimetry may serve as a screening tool between 10 and 14 weeks' gestation for the detection of fetuses with chromosomal abnormalities. Methods: 372 consecutive fetuses were studied. Based on prior study, a chromosomal abnormality was suspected when either the nuchal translucency was above the 95th centile, or there was reversed or absent flow in the ductus venosus during atrial contraction. Sensitivity, specificity, and the negative and positive predictive values were calculated. Results: There were 29 chromosomally abnormal fetuses. of these 29 fetuses, ductus venosus blood flow during atrial contraction was either absent (n = 2) or reversed (n = 25) in 93.1 %. in the chromosomally normal fetuses (n = 343), only 6 (1.7%) had abnormal Doppler profiles in the ductus venosus (specificity = 98.3%, positive and negative predictive values = 81.8% and 99.4%, respectively). Conclusion: the Doppler waveform of the ductus venosus was at least equal to NT thickness measurement for the detection of chromosomal abnormalities. Copyright (C) 2002 S. Karger AG, Basel.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Obstet & Gynecol, São Paulo, Brazil
dc.description.affiliationFed Univ Espirito Santo, Vitoria, Brazil
dc.description.affiliationFed Univ Rio de Janeiro, Rio de Janeiro, Brazil
dc.description.affiliationUniv Maryland, Baltimore, MD 21201 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Obstet & Gynecol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent308-314
dc.identifierhttp://dx.doi.org/10.1159/000063185
dc.identifier.citationFetal Diagnosis and Therapy. Basel: Karger, v. 17, n. 5, p. 308-314, 2002.
dc.identifier.doi10.1159/000063185
dc.identifier.issn1015-3837
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26972
dc.identifier.wosWOS:000177631000013
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofFetal Diagnosis and Therapy
dc.rightsAcesso restrito
dc.rights.licensehttp://www.karger.com/Services/RightsPermissions
dc.subjectDoppler velocimetryen
dc.subjectductus venosusen
dc.subjectnuchal translucencyen
dc.subjectchromosomal abnormalitiesen
dc.titleApplication of ductus venosus Doppler velocimetry for the detection of fetal aneuploidy in the first trimester of pregnancyen
dc.typeArtigo
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