Efficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-Analysis

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dc.citation.issue1
dc.citation.volume17
dc.contributor.authorLopes, Celso [UNIFESP]
dc.contributor.authorTrevisani, Virginia Fernandes Moca [UNIFESP]
dc.contributor.authorMelnik, Tamara [UNIFESP]
dc.coverageNorthcote
dc.date.accessioned2020-11-03T14:40:36Z
dc.date.available2020-11-03T14:40:36Z
dc.date.issued2016
dc.description.abstractBackground Various phototherapy methods are used to treat vitiligo; however, the recent emergence of new devices has heightened debate concerning the best treatment method. Objective We aimed to systematically review and meta-analyze published data comparing the efficacy and adverse effects of monochromatic excimer lamps versus excimer laser and narrowband ultraviolet B (NB-UVB) in treating vitiligo. Methods A systematic search of PubMed, EMBASE, LILACS, Cochrane Central Register of Controlled Trials (CENTRAL), and clinical trials registries identified randomized controlled trials that included vitiligo patients, regardless of age, sex, or study language. We evaluated studies comparing excimer lamps with excimer laser or NB-UVB phototherapy. Results The review included six studies (411 patients, 764 lesions). No study found significantly different efficacy between excimer lamps and excimer laser using the outcomes of >= 50 % repigmentation [risk ratio (RR) = 0.97, 95 % confidence interval (CI) 0.84-1.11] and >= 75 % repigmentation (RR = 0.96, 95 % CI 0.71-1.30). Likewise, no study found significant differences between excimer lamps and NB-UVB (RR = 1.14, 95 % CI 0.88-1.48 for >= 50 % repigmentation; RR = 1.81, 95 % CI 0.11-29.52 for >= 75 % repigmentation). Adverse effects were mild, including pruritus, burning sensation, and dryness, none of which interrupted treatment. Conclusions To our knowledge, this is the first systematic review of the efficacy and safety of excimer lamp treatment for vitiligo. Excimer lamps, excimer laser, and NB-UVB are all safe and effective in repigmentation of vitiligo lesions. Safety, effectiveness, and cost are considerations when choosing treatment.en
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Dermatol, Sao Paulo, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Div Emergency Med & Evidence Based Med, Sao Paulo, Brazil
dc.description.affiliationSanto Amaro Univ UNISA, Discipline Rheumatol, Sao Paulo, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Internal Med & Evidence Based Med, Sao Paulo, Brazil
dc.description.affiliationBrazilian Cochrane Ctr, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Disciplina Med Baseada Evidencia, Rua Botucatu,740-3 Andar Vila Clementino, BR-04023900 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Dept Dermatol, Sao Paulo, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Div Emergency Med & Evidence Based Med, Sao Paulo, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Internal Med & Evidence Based Med, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Disciplina Med Baseada Evidencia, Rua Botucatu,740-3 Andar Vila Clementino, BR-04023900 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent23-32
dc.identifierhttps://doi.org/10.1007/s40257-015-0164-2
dc.identifier.citationAmerican Journal Of Clinical Dermatology. Northcote, v. 17, n. 1, p. 23-32, 2016.
dc.identifier.doi10.1007/s40257-015-0164-2
dc.identifier.issn1175-0561
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58635
dc.identifier.wosWOS:000368988100003
dc.language.isoeng
dc.publisherAdis Int Ltd
dc.relation.ispartofAmerican Journal Of Clinical Dermatology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleEfficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-Analysisen
dc.typeinfo:eu-repo/semantics/article
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