The plus-maze discriminative avoidance task: a new model to study memory-anxiety interactions. Effects of chlordiazepoxide and caffeine

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dc.contributor.authorSilva, R. H.
dc.contributor.authorFrussa, R.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:31:11Z
dc.date.available2016-01-24T12:31:11Z
dc.date.issued2000-10-30
dc.description.abstractThe plus-maze discriminative avoidance paradigm is a new animal model of learning/memory that provides simultaneous information about anxiety. Mice are conditioned to choose between the two enclosed arms tin one of which light and noise are presented as aversive stimuli) while avoiding the two open arms of the apparatus. the test has the advantage of measuring, at the same time and in the same animals, learning/memory (by the percent time spent in aversive enclosed arm - PTAV) and anxiety (by the percent time spent in the open arms - PTO). the effects of chlordiazepoxide and caffeine on learning/memory and anxiety of mice tested in this paradigm were investigated. Chlordiazepoxide (5 mg/kg) significantly increased and caffeine (20 mg/kg) significantly decreased PTO during the training session, suggesting an anxiolytic and an anxiogenic effect, respectively. in the test session, chlordiazepoxide- or caffeine-treated mice presented higher PTAV, suggesting amnestic effects. Given together, chlordiazepoxide plus caffeine did not alter PTO, and the amnesic effect produced by each drug was no longer observed. It is concluded that learning/memory depends on an optimum emotional level. the pins-maze discriminative avoidance model appears to be a useful test to investigate this critical relationship between learning/memory and anxiety. (C) 2000 Elsevier Science B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent117-125
dc.identifierhttp://dx.doi.org/10.1016/S0165-0270(00)00289-2
dc.identifier.citationJournal of Neuroscience Methods. Amsterdam: Elsevier B.V., v. 102, n. 2, p. 117-125, 2000.
dc.identifier.doi10.1016/S0165-0270(00)00289-2
dc.identifier.issn0165-0270
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26400
dc.identifier.wosWOS:000165094800004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Neuroscience Methods
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectcaffeineen
dc.subjectchlordiazepoxideen
dc.subjectbehavioren
dc.subjectavoidance-learningen
dc.subjectanxietyen
dc.titleThe plus-maze discriminative avoidance task: a new model to study memory-anxiety interactions. Effects of chlordiazepoxide and caffeineen
dc.typeinfo:eu-repo/semantics/article
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