Clinical interventions for Takayasu arteritis: A systematic review

Página do item simplificado
dc.citation.issue11
dc.citation.volume71
dc.contributor.authorPacheco, Rafael L. [UNIFESP]
dc.contributor.authorCruz Latorraca, Carolina de Oliveira [UNIFESP]
dc.contributor.authorSilva de Souza, Alexandre Wagner [UNIFESP]
dc.contributor.authorPachito, Daniela V. [UNIFESP]
dc.contributor.authorRiera, Rachel [UNIFESP]
dc.coverageHoboken
dc.date.accessioned2020-09-01T13:21:27Z
dc.date.available2020-09-01T13:21:27Z
dc.date.issued2017
dc.description.abstractIntroductionTakayasu arteritis (TA) is a rare systemic vasculitis that affects large vessels often resistant to treatment and associated with high morbidity and mortality. Treatment is defied by the relapsing nature of the disease and frequent adverse effects of corticosteroids and immunosuppressors, rendering failure of treatment in a significant portion of patients. Considering the low quantity and quality of published studies focusing on treatment of TA, synthesis and critical assessment of the available evidence is fundamental to establish recommendations for clinical practice. ObjectiveTo evaluate the effectiveness and safety of clinical interventions for TA. MethodsSystematic review conducted in accordance to recommendations stated in the Cochrane Handbook, with inclusion of all comparative studies focusing on any type of clinical intervention for TA. ResultsFive comparative studies were included (one randomised clinical trial, two non-randomised clinical trials, and two historical cohorts) totalling 342 patients, aiming at the assessment of effectiveness of corticosteroids, immunosuppressors, biologics and other types of pharmacological treatment for distinct clinical presentations of TA. The quality of studies, assessed by the use of instruments developed specifically for each study design, was considered low. Data scarcity and clinical heterogeneity prevented quantitative synthesis (meta-analysis). ConclusionDespite an extensive literature search, few comparative studies with small sample sizes were retrieved. The quality of these studies was considered low, preventing recommendations on effectiveness and safety of the studied interventions for clinical practice. Until new comparative studies with more robust sample sizes are conducted, treatment of TA should be guided individually taking into account the severity of disease and the availability of treatment options.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Evidence Based Hlth Program, Sao Paulo, Brazil
dc.description.affiliationCochrane Brazil, Rua Borges Lagoa, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Discipline Rheumatol, Vasculitis Outpatient Clin, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Discipline Evidence Based Hlth, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Evidence Based Hlth Program, Sao Paulo, Brazil
dc.description.affiliationUnifespCochrane Brazil, Rua Borges Lagoa, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Discipline Rheumatol, Vasculitis Outpatient Clin, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Discipline Evidence Based Hlth, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1111/ijcp.12993
dc.identifier.citationInternational Journal Of Clinical Practice. Hoboken, v. 71, n. 11, p. -, 2017.
dc.identifier.doi10.1111/ijcp.12993
dc.identifier.issn1368-5031
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58273
dc.identifier.wosWOS:000415049800002
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofInternational Journal Of Clinical Practice
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleClinical interventions for Takayasu arteritis: A systematic reviewen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos