Randomized trial - oxybutynin for treatment of persistent plantar hyperhidrosis in women after sympathectomy

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dc.contributor.authorCosta Junior, Altair da Silva [UNIFESP]
dc.contributor.authorLeao, Luiz Eduardo Villaca [UNIFESP]
dc.contributor.authorSucci, José Ernesto [UNIFESP]
dc.contributor.authorPerfeito, João Aléssio Juliano [UNIFESP]
dc.contributor.authorCastelo Filho, Adauto [UNIFESP]
dc.contributor.authorRymkiewicz, Erika
dc.contributor.authorMarchetti-Filho, Marco Aurelio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:46:55Z
dc.date.available2015-06-14T13:46:55Z
dc.date.issued2014-02-01
dc.description.abstractOBJECTIVE: Hyperhidrosis is a common disease, and thoracoscopic sympathectomy improves its symptoms in up to 95% of cases. Unfortunately, after surgery, plantar hyperhidrosis may remain in 50% of patients, and compensatory sweating may be observed in 70%. This clinical scenario remains a challenge. Our objective was to evaluate the effectiveness of oxybutynin in the treatment of persistent plantar hyperhidrosis and compensatory sweating and its effects on quality of life in women after thoracoscopic sympathectomy. METHOD: We conducted a prospective, randomized study to compare the effects of oxybutynin at 10 mg daily and placebo in women with persistent plantar hyperhidrosis. The assessment was performed using a quality-of-life questionnaire for hyperhidrosis and sweating measurement with a device for quantifying transepidermal water loss. Clinicaltrials.gov: NCT01328015. RESULTS: Sixteen patients were included in each group (placebo and oxybutynin). There were no significant differences between the groups prior to treatment. After oxybutynin treatment, there was a decrease in symptoms and clinical improvement based on the quality-of-life questionnaire (before treatment, 40.4 vs. after treatment, 17.5; p = 0.001). The placebo group showed modest improvement (p = 0.09). The outcomes of the transepidermal water loss measurements in the placebo group showed no differences (p = 0.95), whereas the oxybutynin group revealed a significant decrease (p = 0.001). The most common side effect was dry mouth (100% in the oxybutynin group vs. 43.8% in the placebo group; p = 0.001). CONCLUSION: Oxybutynin was effective in the treatment of persistent plantar hyperhidrosis, resulting in a better quality of life in women who had undergone thoracoscopic sympathectomy.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Department of Thoracic Surgery
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Department of Infectious Diseases
dc.description.affiliationUnifespUNIFESP, EPM, Department of Thoracic Surgery
dc.description.affiliationUnifespUNIFESP, EPM, Department of Infectious Diseases
dc.description.provenanceMade available in DSpace on 2015-06-14T13:46:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-02-01. Added 1 bitstream(s) on 2015-08-11T04:03:59Z : No. of bitstreams: 1 S1807-59322014000200101.pdf: 247749 bytes, checksum: 5485bb812160080db745bbdc38400fb6 (MD5)en
dc.description.sourceSciELO
dc.format.extent101-105
dc.identifierhttp://dx.doi.org/10.6061/clinics/2014(02)05
dc.identifier.citationClinics. Faculdade de Medicina / USP, v. 69, n. 2, p. 101-105, 2014.
dc.identifier.doi10.6061/clinics/2014(02)05
dc.identifier.fileS1807-59322014000200101.pdf
dc.identifier.issn1807-5932
dc.identifier.issn1980-5322
dc.identifier.scieloS1807-59322014000200101
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/8219
dc.identifier.wosWOS:000331931800005
dc.language.isoeng
dc.publisherFaculdade de Medicina / USP
dc.relation.ispartofClinics
dc.rightsAcesso aberto
dc.subjectHyperhidrosisen
dc.subjectThoracic Surgeryen
dc.subjectOxybutyninen
dc.titleRandomized trial - oxybutynin for treatment of persistent plantar hyperhidrosis in women after sympathectomyen
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