Increased number and function of natural killer cells in human immunodeficiency virus 1-positive subjects co-infected with herpes simplex virus 2

Página do item simplificado
dc.contributor.authorLong, Brian R.
dc.contributor.authorErickson, Ann E.
dc.contributor.authorChapman, Joan M.
dc.contributor.authorBarbour, Jason D.
dc.contributor.authorVu, Bien-Aimee N.
dc.contributor.authorHo, Emily L.
dc.contributor.authorLanier, Lewis L.
dc.contributor.authorSauer, Mariana M. [UNIFESP]
dc.contributor.authorCarvalho, Karina I. [UNIFESP]
dc.contributor.authorNixon, Douglas F.
dc.contributor.authorKallas, Esper G. [UNIFESP]
dc.contributor.institutionUniv Calif San Francisco
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T13:59:12Z
dc.date.available2016-01-24T13:59:12Z
dc.date.issued2010-02-01
dc.description.abstractP>Natural killer (NK) cells bridge the interface between innate and adaptive immunity and are implicated in the control of herpes simplex virus 2 (HSV-2) infection. in subjects infected with human immunodeficiency virus 1 (HIV-1), the critical impact of the innate immune response on disease progression has recently come into focus. Higher numbers of NK cells are associated with lower HIV-1 plasma viraemia. Individuals with the compound genotype of killer cell immunoglobulin-like receptor (KIR) 3DS1 and human leucocyte antigen (HLA)-Bw4-80I, or who have alleles of KIR3DL1 that encode proteins highly expressed on the NK cell surface, have a significant delay in disease progression. We studied the effect of HSV-2 co-infection in HIV-1-infected subjects, and show that HSV-2 co-infection results in a pan-lymphocytosis, with elevated absolute numbers of CD4+ and CD8+ T cells, and NK cells. the NK cells in HSV-2 co-infected subjects functioned more efficiently, with an increase in degranulation after in vitro stimulation. the number of NK cells expressing the activating receptors NKp30 and NKp46, and expressing KIR3DL1 or KIR3DS1, was inversely correlated with HIV-1 plasma viral load in subjects mono-infected with HIV-1, but not in subjects co-infected with HSV-2. This suggests that HSV-2 infection mediates changes within the NK cell population that may affect immunity in HIV-1 infection.en
dc.description.affiliationUniv Calif San Francisco, Div Expt Med, Dept Med, San Francisco, CA 94110 USA
dc.description.affiliationUniv Calif San Francisco, Div HIV AIDS, Dept Med, San Francisco Gen Hosp, San Francisco, CA 94110 USA
dc.description.affiliationUniv Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94110 USA
dc.description.affiliationUniv Calif San Francisco, Canc Res Inst, San Francisco, CA 94110 USA
dc.description.affiliationUniversidade Federal de São Paulo, Div Infect Dis, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Div Clin Immunol & Allergy, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Infect Dis, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Institute of Allergies and Infectious Diseases
dc.description.sponsorshipBrazilian Program
dc.description.sponsorshipMinistry of Health
dc.description.sponsorshipSão Paulo City Health Department
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipJohn E. Fogarty International Center
dc.description.sponsorshipAIDS Research Institute of the AIDS Biology Program at UCSF
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDNational Institute of Allergies and Infectious Diseases: NIAID AI060379
dc.description.sponsorshipIDNational Institute of Allergies and Infectious Diseases: AI052731
dc.description.sponsorshipIDNational Institute of Allergies and Infectious Diseases: AI064520
dc.description.sponsorshipIDNational Institute of Allergies and Infectious Diseases: AI64520
dc.description.sponsorshipIDNational Institute of Allergies and Infectious Diseases: AI-066917
dc.description.sponsorshipIDNational Institute of Allergies and Infectious Diseases: AI-076014
dc.description.sponsorshipIDMinistry of Health: 914/BRA/3014 - UNESCO/Kallas
dc.description.sponsorshipIDSão Paulo City Health Department: 2004-0.168.922-7/Kallas
dc.description.sponsorshipIDFAPESP: 04/15 856-9/Kallas
dc.description.sponsorshipIDJohn E. Fogarty International Center: D43 TW00003
dc.format.extent186-196
dc.identifierhttp://dx.doi.org/10.1111/j.1365-2567.2009.03170.x
dc.identifier.citationImmunology. Malden: Wiley-Blackwell Publishing, Inc, v. 129, n. 2, p. 186-196, 2010.
dc.identifier.doi10.1111/j.1365-2567.2009.03170.x
dc.identifier.issn0019-2805
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32189
dc.identifier.wosWOS:000273458000005
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofImmunology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectCD107en
dc.subjectherpes simplex virus 2en
dc.subjecthuman immunodeficiency virusen
dc.subjectkiller cell immunoglobulin-like receptoren
dc.subjectnatural killer cellsen
dc.titleIncreased number and function of natural killer cells in human immunodeficiency virus 1-positive subjects co-infected with herpes simplex virus 2en
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
Em verificação - Geral