Distinct behavioral phenotypes in ethanol-induced place preference are associated with different extinction and reinstatement but not behavioral sensitization responses

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dc.contributor.authorPildervasser, João Victor Nicodemos [UNIFESP]
dc.contributor.authorAbrahao, Karina Possa [UNIFESP]
dc.contributor.authorSouza-Formigoni, Maria Lucia Oliveira de [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionNIAAA
dc.date.accessioned2016-01-24T14:37:43Z
dc.date.available2016-01-24T14:37:43Z
dc.date.issued2014-08-08
dc.description.abstractConditioned place preference (CPP) is a model to study the role of drug conditioning properties. in outbred strains, individual variability may affect some behavioral measures. However, there are few studies focusing on understanding how different phenotypes of ethanol conditioned behavior may influence its extinction, reinstatement, and behavioral adaptation measures. We used male Swiss Webster mice to study different phenotypes related to ethanol conditioning strength, reinstatement and behavioral sensitization. Mice went through a CPP procedure with ethanol (2.2 g/kg, i.p.). After that, one group of mice was submitted to repeated extinction sessions, while another group remained in their home cages without any drug treatment. Mice went through environmental and ethanol priming (1.0 g/kg, i.p.) reinstatement tests. Ethanol priming test reinstated the conditioned behavior only in the animals kept in the home-cage during the abstinence period. Besides, the ethanol conditioned behavior strength was positively correlated with the time required to be extinguished. in the second set of experiments, some mice went through a CPP protocol followed by behavioral sensitization (five i.p. administrations of ethanol 2.2 g/kg or saline per week, for 3 weeks) and another group of mice went through sensitization followed by CPR No positive correlation was observed between ethanol CPP strength and the intensity of behavioral sensitization. Considering that different phenotypes observed in CPP strength predicted the variability in other CPP measures, we developed a statistics-based method to classify mice according to CPP strength to be used in the evaluation of ethanol conditioning properties.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, Unidade Dependencia Drogas, São Paulo, Brazil
dc.description.affiliationNIAAA, Lab Integrat Neurosci, NIH, Rockville, MD 20852 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, Unidade Dependencia Drogas, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipAFIP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2011/15258-8
dc.format.extent11
dc.identifierhttp://dx.doi.org/10.3389/fnbeh.2014.00267
dc.identifier.citationFrontiers in Behavioral Neuroscience. Lausanne: Frontiers Research Foundation, v. 8, 11 p., 2014.
dc.identifier.doi10.3389/fnbeh.2014.00267
dc.identifier.fileWOS000340903100001.pdf
dc.identifier.issn1662-5153
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38084
dc.identifier.wosWOS:000340903100001
dc.language.isoeng
dc.publisherFrontiers Research Foundation
dc.relation.ispartofFrontiers in Behavioral Neuroscience
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbehavioral sensitizationen
dc.subjectCPPen
dc.subjectdifferent phenotypesen
dc.subjectethanolen
dc.subjectextinctionen
dc.subjectindividual variabilityen
dc.titleDistinct behavioral phenotypes in ethanol-induced place preference are associated with different extinction and reinstatement but not behavioral sensitization responsesen
dc.typeinfo:eu-repo/semantics/article
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