Brazilian Network for HIV Drug Resistance Surveillance: a survey of individuals recently diagnosed with HIV

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dc.contributor.authorInocencio, Lilian A.
dc.contributor.authorPereira, Anderson A.
dc.contributor.authorSucupira, Maria Cecilia A. [UNIFESP]
dc.contributor.authorFernandez, Jose Carlos C.
dc.contributor.authorJorge, Celia P.
dc.contributor.authorSouza, Denise F. C.
dc.contributor.authorFink, Helena T.
dc.contributor.authorDiaz, Ricardo Sobhie [UNIFESP]
dc.contributor.authorBecker, Irina M.
dc.contributor.authorSuffert, Theodoro A.
dc.contributor.authorArruda, Monica B.
dc.contributor.authorMacedo, Olinda
dc.contributor.authorSimao, Mariangela B. G.
dc.contributor.authorTanuri, Amilcar
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionMinist Hlth
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionIOC FIOCRUZ
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)
dc.contributor.institutionPubl Hlth Lab LACEN Brasilia
dc.contributor.institutionPubl Hlth Lab LACEN
dc.contributor.institutionMunicipatil Porto Alegre
dc.date.accessioned2016-01-24T13:52:00Z
dc.date.available2016-01-24T13:52:00Z
dc.date.issued2009-01-01
dc.description.abstractUse of antiretrovirals is widespread in Brazil, where more than 200,000 individuals are under treatment. Although general prevalence of primary antiretroviral resistance in Brazil is low, systematic sampling in large metropolitan areas has not being performed.The HIV Threshold Survey methodology (HIV-THS, WHO) was utilized, targeting Brazil's four major regions and selecting the six most populated state capitals: São Paulo, Rio de Janeiro, Salvador, Porto Alegre, Brasilia and Belem. We were able to sequence samples from 210 individuals with recent HIV diagnosis, 17 of them (8.1%) carrying HIV isolates with primary antiretroviral resistance mutations. Five, nine and four isolates showed mutations related to resistance to nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs), respectively. Using HIV-THS, we could find an intermediate level of transmitted resistance (5% to 15%) in Belem/Brasilia, São Paulo and Rio de Janeiro. Lower level of transmitted resistance (<5%) were observed in the other areas. Despite the extensive antiretroviral exposure and high rates of virologic antiretroviral failure in Brazil, the general prevalence of primary resistance is still low. However, an intermediate level of primary resistance was found in the four major Brazilian cities, confirming the critical need to start larger sampling surveys to better define the risk factors associated with transmission of resistant HIV.en
dc.description.affiliationIB UFRJ, Mol Virol Lab, Rio de Janeiro, Brazil
dc.description.affiliationMinist Hlth, Brazilian DST AIDS Program, Brasilia, DF, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Lab Retrovirol, São Paulo, Brazil
dc.description.affiliationIOC FIOCRUZ, Lab Imunol, Rio de Janeiro, RJ, Brazil
dc.description.affiliationUniv Fed Bahia, Mol Biol Lab, Salvador, BA, Brazil
dc.description.affiliationPubl Hlth Lab LACEN Brasilia, Brasilia, DF, Brazil
dc.description.affiliationPubl Hlth Lab LACEN, Porto Alegre, RS, Brazil
dc.description.affiliationMunicipatil Porto Alegre, Hlth Ctr Porto, Porto Alegre, RS, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Lab Retrovirol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipBrazilian Ministry of Health
dc.description.sponsorshipUNESCO
dc.description.sponsorshipUNDOC
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent6
dc.identifierhttp://dx.doi.org/10.1186/1758-2652-12-20
dc.identifier.citationJournal of the International Aids Society. London: Biomed Central Ltd, v. 12, 6 p., 2009.
dc.identifier.doi10.1186/1758-2652-12-20
dc.identifier.fileWOS000208106500020.pdf
dc.identifier.issn1758-2652
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31121
dc.identifier.wosWOS:000208106500020
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofJournal of the International Aids Society
dc.rightsAcesso aberto
dc.titleBrazilian Network for HIV Drug Resistance Surveillance: a survey of individuals recently diagnosed with HIVen
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