Effects of brief and long maternal separations on the HPA axis activity and the performance of rats on context and tone fear conditioning

Página do item simplificado
dc.contributor.authorGuijarro, Jussara Z.
dc.contributor.authorTiba, Paula A.
dc.contributor.authorFerreira, Tatiana L.
dc.contributor.authorKawakami, Suzi E.
dc.contributor.authorOliveira, Maria Gabriela M.
dc.contributor.authorSuchecki, Deborah
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:49:16Z
dc.date.available2016-01-24T13:49:16Z
dc.date.issued2007-12-03
dc.description.abstractPrevious studies show that early life events result in neurobehavioural alterations that may be either beneficial or detrimental to the stress response. Given the close relationship between corticosterone secretion and mnemonic processes, the purpose of the present study was to investigate the effects of brief (BMS, 15 min) and long maternal separations (LMS, 180 min) on memory tasks in adult rats, assessed by context and tone fear conditioning. At adulthood, males were evaluated for behavioural and hormonal reaction to the training environment, being tested for context fear conditioning; tone fear conditioning; and learning curve in the context fear conditioning, in which rats were daily re-exposed to the context, followed by a brief footshock and in the last day of the experiment (day 5) animals were exposed to the context. Corticosterone and ACTH plasma levels were determined in naive rats (basal) or 5, 25 or 45 min after each test. Peak ACTH and corticosterone levels were similar among the groups after context fear conditioning; however, levels of CTL rats remained elevated for a longer time. in the learning curve of context fear conditioning, both BMS and LMS rats exhibited less freezing behaviour than CTL rats, without differences in hormone secretion. There was neither an association between activity of the HPA axis and performance on memory tasks nor different activational properties of the tasks on the HPA axis between BMS and LMS rats, i.e., both manipulations lead to similar performance in hippocampus-dependent and independent memory tasks. (C) 2007 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent101-108
dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2007.06.020
dc.identifier.citationBehavioural Brain Research. Amsterdam: Elsevier B.V., v. 184, n. 2, p. 101-108, 2007.
dc.identifier.doi10.1016/j.bbr.2007.06.020
dc.identifier.issn0166-4328
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30206
dc.identifier.wosWOS:000250906500001
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBehavioural Brain Research
dc.rightsAcesso restrito
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectlong maternal separationen
dc.subjectbrief maternal separationen
dc.subjectcontext fear conditioningen
dc.subjecttone fear conditioningen
dc.subjectHPA axisen
dc.subjectWistar ratsen
dc.titleEffects of brief and long maternal separations on the HPA axis activity and the performance of rats on context and tone fear conditioningen
dc.typeArtigo
Arquivos
Coleções
Em verificação - Geral