Neuro-Immuno-Endocrine Modulation in Marathon Runners
dc.contributor.author | Bachi, Andre Luis Lacerda [UNIFESP] | |
dc.contributor.author | Rios, Francisco Jose O. | |
dc.contributor.author | Vaisberg, Pedro Henrique Carr [UNIFESP] | |
dc.contributor.author | Martins, Marcia [UNIFESP] | |
dc.contributor.author | Sa, Matheus Cavalcante de [UNIFESP] | |
dc.contributor.author | Victorino, Angelica Begatti [UNIFESP] | |
dc.contributor.author | Foster, Roberta [UNIFESP] | |
dc.contributor.author | Sierra, Ana Paula R. | |
dc.contributor.author | Kiss, Maria Augusta Peduti Dal'Molin | |
dc.contributor.author | Vaisberg, Mauro [UNIFESP] | |
dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
dc.contributor.institution | Cruzeiro Univ | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | Univ Glasgow | |
dc.date.accessioned | 2016-01-24T14:39:52Z | |
dc.date.available | 2016-01-24T14:39:52Z | |
dc.date.issued | 2015-01-01 | |
dc.description.abstract | Objective: Sports practice alters the homeostasis of athletes. To achieve homeostatic equilibrium, the integrated action of the neuroendocrine and immune systems is necessary. Here we studied the relation between cytokines, hormones and mood states in marathon runners. Methods: A total of 20 male recreational marathon runners (mean age = 35.7 +/- 9 years) and 20 male sedentary individuals (mean age = 35.5 +/- 7 years) were recruited. We compared the serum levels of growth hormone (GH), cortisol and interleukins 8 and 10 and the amounts of these two cytokines spontaneously produced by peripheral blood mononuclear cells. Blood samples of the sedentary group were collected at rest. Blood from the marathon runners was collected at rest (baseline: 24 h before the race), immediately after a marathon and 72 h after a marathon. Mood state analysis in both groups was performed using the 24-item Brunel Mood Scale (BRUMS). Results: Our results showed that, at rest, levels of interleukins 8 and 10 in the supernatant of culture cells, the serum concentration of GH, and tension and vigour (evaluated using the BRUMS), were significantly higher in athletes compared to sedentary people. Immediately after the race all serum parameters analysed were statistically higher than baseline values. At 72 h after the marathon, serum levels of hormones and interleukins returned to values at rest, but the concentrations of interleukins in the supernatant of culture cells showed a significant reduction compared to values at rest. Conclusion: the higher serum levels of GH in athletes at rest and the higher production of cytokines in culture without previous stimulus suggest that marathon runners present mechanisms that may be associated with preparing the body to perform prolonged strenuous exercise, such as a marathon. (C) 2014 S. Karger AG, Basel | en |
dc.description.affiliation | Universidade Federal de São Paulo, Dept Microbiol & Immunol, São Paulo, Brazil | |
dc.description.affiliation | Cruzeiro Univ, Inst Phys Act & Sport Sci, São Paulo, Brazil | |
dc.description.affiliation | Univ São Paulo, Inst Biomed Sci, Dept Immunol, São Paulo, Brazil | |
dc.description.affiliation | Univ Glasgow, British Heart Fdn Glasgow Cardiovasc Res Ctr, Inst Cardiovasc & Med Sci, Glasgow G12 8QQ, Lanark, Scotland | |
dc.description.affiliation | Universidade Federal de São Paulo, Dept Otorhinolaryngol, São Paulo, Brazil | |
dc.description.affiliation | Universidade Federal de São Paulo, Dept Neurol & Neurosurg, São Paulo, Brazil | |
dc.description.affiliation | Universidade Federal de São Paulo, Dept Gynaecol, São Paulo, Brazil | |
dc.description.affiliation | Univ São Paulo, Sch Phys Educ & Sport, São Paulo, Brazil | |
dc.description.affiliationUnifesp | Universidade Federal de São Paulo, Dept Microbiol & Immunol, São Paulo, Brazil | |
dc.description.affiliationUnifesp | Universidade Federal de São Paulo, Dept Otorhinolaryngol, São Paulo, Brazil | |
dc.description.affiliationUnifesp | Universidade Federal de São Paulo, Dept Neurol & Neurosurg, São Paulo, Brazil | |
dc.description.affiliationUnifesp | Universidade Federal de São Paulo, Dept Gynaecol, São Paulo, Brazil | |
dc.description.source | Web of Science | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorshipID | FAPESP: 2010/50025-1 | |
dc.format.extent | 196-202 | |
dc.identifier | https://dx.doi.org/10.1159/000363061 | |
dc.identifier.citation | Neuroimmunomodulation. Basel: Karger, v. 22, n. 3, p. 196-202, 2015. | |
dc.identifier.doi | 10.1159/000363061 | |
dc.identifier.issn | 1021-7401 | |
dc.identifier.uri | https://repositorio.unifesp.br/handle/11600/38612 | |
dc.identifier.wos | WOS:000348100600007 | |
dc.language.iso | eng | |
dc.publisher | Karger | |
dc.relation.ispartof | Neuroimmunomodulation | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.license | http://www.karger.com/Services/RightsPermissions | |
dc.subject | Cytokines | en |
dc.subject | Exercise | en |
dc.subject | Stress hormone | en |
dc.subject | Behaviour | en |
dc.subject | Brunel Mood Scale | en |
dc.title | Neuro-Immuno-Endocrine Modulation in Marathon Runners | en |
dc.type | info:eu-repo/semantics/article |