Resistance Training with Instability in Multiple System Atrophy: A Case Report

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dc.contributor.authorSilva-Batista, Carla
dc.contributor.authorKanegusuku, Helcio
dc.contributor.authorRoschel, Hamilton
dc.contributor.authorSouza, Eduardo O.
dc.contributor.authorCunha, Telma F.
dc.contributor.authorLaurentino, Gilberto Candido
dc.contributor.authorManoel, N.
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorPiemonte, Maria Elisa Pimentel
dc.contributor.authorBrum, Patricia Chakur
dc.contributor.authorForjaz, Cláudia Lúcia de Moraes
dc.contributor.authorTricoli, Valmor
dc.contributor.authorUgrinowitsch, Carlos
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T10:46:16Z
dc.date.available2018-06-18T10:46:16Z
dc.date.issued2014-09-01
dc.description.abstractThis case report assessed quality of life, activities of daily living, motor symptoms, functional ability, neuromuscular parameters and mRNA expression of selected genes related to muscle protein synthesis and degradation in a patient with Multiple System Atrophy (MSA). The patient underwent resistance training with instability devices (i.e., bosu, dyna disk, balance disk, Swiss ball) for six months twice a week. After the six months training, the patient's left and right quadriceps muscle cross-sectional area and leg press one-repetition maximum increased 6.4%, 6.8%, and 40%, respectively; the patient's timed up and go, sit to stand, dynamic balance, and activities of daily living improved 33.3%, 28.6%, 42.3%, and 40.1%, respectively; the patient's severity of motor symptoms and risk of falls decreased 32% and 128.1%, respectively. Most of the subscales of quality of life demonstrated improvements as well, varying from 13.0% to 100.0%. mRNA expression of mechanogrowth factor and mammalian target of rapamycin increased 12.7-fold and 1.5-fold, respectively. This case report describes likely the first nonpharmacological therapeutic tool that might be able to decrease the severity of motor symptoms and risk of falls, and to improve functional ability, neuromuscular parameters, and quality of the life in a patient with MSA.en
dc.description.affiliationUniv Sao Paulo, Sch Phys Educ & Sport, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Div Rheumatol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Ctr Psychobiol & Exercise Studies, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Phys Therapy, Fac Med Sci, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Ctr Psychobiol & Exercise Studies, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo Pesquisa do Estado de Sao Paulo
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFundacao de Amparo Pesquisa do Estado de Sao Paulo: 2012/03056-4
dc.description.sponsorshipIDFundacao de Amparo Pesquisa do Estado de Sao Paulo: 2013/04970-4
dc.description.sponsorshipIDCNPq: 304205/2011-7
dc.description.sponsorshipIDCNPq: 152658/2011-5
dc.description.sponsorshipIDCNPq: 304814/2010-5
dc.format.extent597-603
dc.identifierhttps://www.jssm.org/casejssm-13-597.xml.xml
dc.identifier.citationJournal Of Sports Science And Medicine. Bursa: Journal Sports Science & Medicine, v. 13, n. 3, p. 597-603, 2014.
dc.identifier.issn1303-2968
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/44701
dc.identifier.wosWOS:000340753400019
dc.language.isoeng
dc.publisherJournal Sports Science & Medicine
dc.relation.ispartofJournal Of Sports Science And Medicine
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectExercise trainingen
dc.subjectRisk of fallsen
dc.subjectMotor symptomsen
dc.subjectCross-sectional areaen
dc.titleResistance Training with Instability in Multiple System Atrophy: A Case Reporten
dc.typeinfo:eu-repo/semantics/article
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